应激/细胞死亡途径、神经炎症和神经性疼痛。

IF 7.5 2区 医学 Q1 IMMUNOLOGY Immunological Reviews Pub Date : 2023-09-08 DOI:10.1111/imr.13275
Lu Li, Tian Li, Xinyu Qu, Guangwei Sun, Qi Fu, Guang Han
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引用次数: 0

摘要

神经性疼痛是由躯体感觉神经系统的病变或疾病引起的一种常见的、使人衰弱的慢性疼痛。尽管阐明了许多病理生理学机制并开发了潜在的治疗化合物,但安全可靠的神经病理性疼痛治疗方法仍然匮乏。多种应激/细胞死亡途径已被证明与神经病理性疼痛过程中的神经炎症有关。在此,我们总结了目前有关应激/细胞死亡途径的知识,并概述了应激/细胞死亡途径在神经病理性疼痛期间神经炎症中的作用和分子机制,包括内在和外在凋亡、自噬、有丝分裂、铁凋亡、热凋亡、坏死凋亡和吞噬。主要基于临床前神经病理性疼痛模型,讨论了调节应激/细胞死亡途径以缓解神经病理性疼痛的小分子化合物。这些发现将有助于深入了解神经病理性疼痛的病理过程,并弥合基础研究与转化研究之间的差距,从而发现新的神经保护干预措施。
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Stress/cell death pathways, neuroinflammation, and neuropathic pain

Neuropathic pain is a common and debilitating modality of chronic pain induced by a lesion or disease of the somatosensory nervous system. Albeit the elucidation of numerous pathophysiological mechanisms and the development of potential treatment compounds, safe and reliable therapies of neuropathic pain remain poor. Multiple stress/cell death pathways have been shown to be implicated in neuroinflammation during neuropathic pain. Here, we summarize the current knowledge of stress/cell death pathways and present an overview of the roles and molecular mechanisms of stress/cell death pathways in neuroinflammation during neuropathic pain, covering intrinsic and extrinsic apoptosis, autophagy, mitophagy, ferroptosis, pyroptosis, necroptosis, and phagoptosis. Small molecule compounds that modulate stress/cell death pathways in alleviating neuropathic pain are discussed mainly based on preclinical neuropathic pain models. These findings will contribute to in-depth understanding of the pathological processes during neuropathic pain as well as bridge the gap between basic and translational research to uncover new neuroprotective interventions.

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来源期刊
Immunological Reviews
Immunological Reviews 医学-免疫学
CiteScore
16.20
自引率
1.10%
发文量
118
审稿时长
4-8 weeks
期刊介绍: Immunological Reviews is a specialized journal that focuses on various aspects of immunological research. It encompasses a wide range of topics, such as clinical immunology, experimental immunology, and investigations related to allergy and the immune system. The journal follows a unique approach where each volume is dedicated solely to a specific area of immunological research. However, collectively, these volumes aim to offer an extensive and up-to-date overview of the latest advancements in basic immunology and their practical implications in clinical settings.
期刊最新文献
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