肥胖与衰老之间的联系——深入了解心脏能量代谢。

IF 5.3 3区医学 Q2 CELL BIOLOGY Mechanisms of Ageing and Development Pub Date : 2023-09-07 DOI:10.1016/j.mad.2023.111870

Patricia Owesny , Tilman Grune

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引用次数: 0

摘要

肥胖和衰老是一系列疾病的公认风险因素，包括心血管疾病和2型糖尿病。鉴于肥胖患病率不断上升、人口老龄化以及随后心血管疾病的增加，研究相关的潜在机制至关重要。衰老和肥胖都通过各种机制对能量代谢产生深远影响，包括代谢不灵活、能量产生的底物利用率改变、营养感知失调和线粒体功能障碍。在这篇综述中，我们旨在提出并讨论这样一种假设，即肥胖由于其在衰老心脏中观察到的变化相似，可能会加速心脏衰老过程，并加剧老年肥胖患者的临床结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The link between obesity and aging - insights into cardiac energy metabolism

Obesity and aging are well-established risk factors for a range of diseases, including cardiovascular diseases and type 2 diabetes. Given the escalating prevalence of obesity, the aging population, and the subsequent increase in cardiovascular diseases, it is crucial to investigate the underlying mechanisms involved. Both aging and obesity have profound effects on the energy metabolism through various mechanisms, including metabolic inflexibility, altered substrate utilization for energy production, deregulated nutrient sensing, and mitochondrial dysfunction. In this review, we aim to present and discuss the hypothesis that obesity, due to its similarity in changes observed in the aging heart, may accelerate the process of cardiac aging and exacerbate the clinical outcomes of elderly individuals with obesity.

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来源期刊

Mechanisms of Ageing and Development 医学-老年医学

CiteScore

11.10

自引率

1.90%

发文量

审稿时长

32 days

期刊介绍： Mechanisms of Ageing and Development is a multidisciplinary journal aimed at revealing the molecular, biochemical and biological mechanisms that underlie the processes of aging and development in various species as well as of age-associated diseases. Emphasis is placed on investigations that delineate the contribution of macromolecular damage and cytotoxicity, genetic programs, epigenetics and genetic instability, mitochondrial function, alterations of metabolism and innovative anti-aging approaches. For all of the mentioned studies it is necessary to address the underlying mechanisms. Mechanisms of Ageing and Development publishes original research, review and mini-review articles. The journal also publishes Special Issues that focus on emerging research areas. Special issues may include all types of articles following peered review. Proposals should be sent directly to the Editor-in-Chief.