栀竹宽中胶囊与多虑平治疗难治性功能性消化不良的柱头和疗效:一项随机对照试验。

IF 3.3 3区 医学 Q2 CLINICAL NEUROLOGY Journal of Neurogastroenterology and Motility Pub Date : 2023-07-30 DOI:10.5056/jnm22145
Qian-Qian Wang, Li Cheng, Bi-Yu Wu, Hong-Yi Qiu, Ping Xu, Bo Wang, Xiu-Juan Yan, Sheng-Liang Chen
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引用次数: 0

摘要

背景/目的:与抗抑郁药相关的耻辱感在功能性消化不良患者中普遍存在。它影响药物依从性和疗效。在亚洲,草药在缓解消化不良症状方面获得了根深蒂固的文化认同。本研究旨在比较止痫宽中胶囊(ZZKZ)与盐酸多塞平(doxepin hydrochloride)在缓解难治性FD (rFD)患者的耻辱感和药物依从性方面的疗效。方法:从2021年2月至2022年2月,随机分配患有rFD的患者接受多赛平(n = 56)或ZZKZ (n = 57)联合奥美拉唑治疗4周。分析药物占有率(MPR)、疾病和药物相关的耻辱感。使用量表评估消化不良症状(利兹消化不良问卷)和心理状况(广泛性焦虑障碍问卷和患者健康问卷)。结果:ZZKZ的MPR值显著高于doxpin (P < 0.001)。治疗后,与基线相比,ZZKZ组的病耻感评分降低,而多塞平组的病耻感评分升高。患者出现zzkz相关病耻感的比例显著低于doxpin相关病耻感的比例(P < 0.001)。两组的MPR值与治疗后柱头评分呈负相关(P < 0.001)。治疗后两组患者消化不良症状及心理状况均有改善,治疗后利兹消化不良问卷、广泛性焦虑障碍问卷、患者健康问卷得分两组间差异无统计学意义。结论:ZZKZ在减轻病耻感和药物依从性方面优于doxepin,在改善rFD患者的消化不良症状和心理状况方面具有相当的疗效。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Stigma and Efficacy of Zhizhu Kuanzhong Capsules Versus Doxepin in the Treatment of Refractory Functional Dyspepsia: A Randomized Controlled Trial.

Background/aims: Stigma related with antidepressants is prevalent in patients with functional dyspepsia. It affects medication compliance and efficacy. Herbal medicine acquired a deep-rooted cultural identity in relieving dyspeptic symptoms in Asians. The research was designed to compare the effectiveness of Zhizhu Kuanzhong capsules (ZZKZ) versus doxepin hydrochloride (doxepin) on alleviating stigma and medication nonadherence among patients with refractory FD (rFD).

Methods: Patients with rFD from February 2021 to February 2022 were randomly allocated to receive either doxepin (n = 56) or ZZKZ (n = 57) combined with omeprazole for 4 weeks. Medication possession ratio (MPR), the disease- and medication-associated stigma were analyzed. The scales were utilized to assess dyspeptic symptoms (Leeds Dyspepsia Questionnaire) and psychological conditions (Generalized Anxiety Disorder Questionnaire and Patient Health Questionnaire).

Results: The MPR values for ZZKZ were significantly higher than those for doxepin (P < 0.001). The stigma scores decreased in ZZKZ group while increased in doxepin group compared to baseline after treatment. The proportion of patients showing ZZKZ-associated stigma was significantly lower than doxepin-associated stigma (P < 0.001). The MPR values were negatively correlated with post-treatment stigma scores in both groups (P < 0.001). Dyspeptic symptoms and psychological condition were improved in both groups after treatment, with no significant difference on post-treatment Leeds Dyspepsia Questionnaire, Generalized Anxiety Disorder Questionnaire, or Patient Health Questionnaire scores between 2 groups.

Conclusion: ZZKZ is superior to doxepin in alleviating stigma and medication non-adherence, with comparable efficacy in improving dyspeptic symptoms and psychological condition of patients with rFD.

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来源期刊
Journal of Neurogastroenterology and Motility
Journal of Neurogastroenterology and Motility GASTROENTEROLOGY & HEPATOLOGY-CLINICAL NEUROLOGY
CiteScore
6.30
自引率
8.80%
发文量
96
期刊介绍: Journal of Neurogastroenterology and Motility (J Neurogastroenterol Motil) is a joint official journal of the Korean Society of Neurogastroenterology and Motility, the Thai Neurogastroenterology and Motility Society, the Japanese Society of Neurogastroenterology and Motility, the Indian Motility and Functional Disease Association, the Chinese Society of Gastrointestinal Motility, the South East Asia Gastro-Neuro Motility Association, the Taiwan Neurogastroenterology and Motility Society and the Asian Neurogastroenterology and Motility Association, launched in January 2010 after the title change from the Korean Journal of Neurogastroenterology and Motility, published from 1994 to 2009.
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