新型冠状病毒神经学表现研究的动物模型

IF 1.3 4区 农林科学 Q2 VETERINARY SCIENCES Comparative medicine Pub Date : 2023-02-01 DOI:10.30802/AALAS-CM-22-000073
Kelsey C Carpenter, Jibing Yang, Jiajie Jessica Xu
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引用次数: 0

摘要

严重急性呼吸综合征冠状病毒2 (SARS-CoV-2)是全球冠状病毒(COVID-19)大流行的病因,估计已感染5.25亿人,其中600多万人死亡。尽管COVID-19主要是一种呼吸道疾病,但据报道,人类出现的神经系统症状越来越多。一些神经系统症状,如嗅觉或味觉丧失,是轻微的。然而,其他症状,如脑膜脑炎或中风,可能是致命的。除了对人类进行调查和死后评估外,科学家们还研究了几种动物物种,试图阐明神经系统症状的原因。由于神经系统的复杂性和神经体征的识别和量化困难,神经系统后遗症的研究仍然具有挑战性。我们回顾了用于神经系统COVID-19研究的动物模型,特别是对小鼠、仓鼠、雪貂和非人灵长类动物的研究。我们总结了SARS-CoV-2在神经系统中的存在及其病理作用。鉴于需要加强对COVID-19及其对神经系统的影响的了解,科学家必须努力从动物身上获得新的信息,以降低人类神经系统并发症的死亡率和发病率。
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Animal Models for the Study of Neurologic Manifestations Of COVID-19.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of the worldwide coronavirus (COVID-19) pandemic, has infected an estimated 525 million people with over 6 million deaths. Although COVID-19 is primarily a respiratory disease, an escalating number of neurologic symptoms have been reported in humans. Some neurologic symptoms, such as loss of smell or taste, are mild. However, other symptoms, such as meningoencephalitis or stroke, are potentially fatal. Along with surveys and postmortem evaluations on humans, scientists worked with several animal species to try to elucidate the causes of neurologic symptoms. Neurologic sequelae remain challenging to study due to the complexity of the nervous system and difficulties in identification and quantification of neurologic signs. We reviewed animal models used in the study of neurologic COVID-19, specifically research in mice, hamsters, ferrets, and nonhuman primates. We summarized findings on the presence and pathologic effects of SARS-CoV-2 on the nervous system. Given the need to increase understanding of COVID-19 and its effects on the nervous system, scientists must strive to obtain new information from animals to reduce mortality and morbidity with neurologic complications in humans.

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来源期刊
Comparative medicine
Comparative medicine 医学-动物学
CiteScore
1.90
自引率
0.00%
发文量
71
审稿时长
6-12 weeks
期刊介绍: Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.
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