高脂饮食诱发非酒精性脂肪肝的自噬功能障碍

IF 14.6 1区生物学 Q1 CELL BIOLOGY Autophagy Pub Date : 2024-02-01 Epub Date: 2023-09-12 DOI:10.1080/15548627.2023.2254191

Qiannan Ren, Qiming Sun, Junfen Fu

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引用次数: 0

摘要

缩写：缩写： ACOX1：酰基-CoA 氧化酶 1；ADH5：醇脱氢酶 5（III 类），chi 多肽；ADIPOQ：含脂肪连蛋白、C1Q 和胶原蛋白结构域；ATG：自噬相关；BECN1：beclin 1；CRTC2：ER：内质网；F2RL1：F2R 类胰蛋白酶受体 1；FA：脂肪酸；FOXO1：叉头框 O1；GLP1R：胰高血糖素样肽 1 受体；GRK2：G 蛋白偶联受体激酶 2；GTPase：HFD：高脂饮食；HSCs：肝星状细胞；HTRA2：HtrA 丝氨酸肽酶 2；IRGM：免疫相关 GTPase M；KD：基因敲除；KDM6B：赖氨酸去甲基化酶 6B；KO：基因敲除；LAMP2：溶酶体相关膜蛋白 2；LAP：LDs：脂滴；Li KO：肝特异性敲除；LSECs：肝窦状内皮细胞；MAP1LC3/LC3：微管相关蛋白 1 轻链 3；MAP3K5：丝裂原活化蛋白激酶激酶 5；MED1：MTOR：雷帕霉素激酶的机制靶点；MTORC1：雷帕霉素复合体的机制靶点 1；NAFLD：非酒精性脂肪肝；NASH：非酒精性脂肪性肝炎；NFE2L2：NFE2：NFE2 like bZIP 转录因子 2；NOS3：一氧化氮合酶 3；NR1H3：核受体亚家族 1 H 组 3；OA：油酸；OE：过表达；OSBPL8：类氧固醇结合蛋白 8；PA：棕榈酸；RUBCNL：卢比肯类自噬增强子；PLIN2：PPARA：过氧化物酶体增殖激活受体α；PRKAA2/AMPK：蛋白激酶 AMP 激活催化亚基α2；RAB：RAS 癌基因家族成员；RPTOR：MTOR 复合物 1 的调节相关蛋白；SCD：SIRT1：sirtuin 1；SIRT3：sirtuin 3；SNARE：可溶性 N-乙基马来酰亚胺敏感因子附着蛋白受体；SQSTM1/p62：序列组 1；SREBF1：固醇调节元件结合转录因子 1；SREBF2：固醇调节元件结合转录因子 2；STING1：STX17：合成酶 17；TAGs：三酰甘油；TFEB：转录因子 EB；TP53/p53：肿瘤蛋白 p53；ULK1：unc-51 类自噬激活激酶 1；VMP1：液泡膜蛋白 1。

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Dysfunction of autophagy in high-fat diet-induced non-alcoholic fatty liver disease.

Abbreviations: ACOX1: acyl-CoA oxidase 1; ADH5: alcohol dehydrogenase 5 (class III), chi polypeptide; ADIPOQ: adiponectin, C1Q and collagen domain containing; ATG: autophagy related; BECN1: beclin 1; CRTC2: CREB regulated transcription coactivator 2; ER: endoplasmic reticulum; F2RL1: F2R like trypsin receptor 1; FA: fatty acid; FOXO1: forkhead box O1; GLP1R: glucagon like peptide 1 receptor; GRK2: G protein-coupled receptor kinase 2; GTPase: guanosine triphosphatase; HFD: high-fat diet; HSCs: hepatic stellate cells; HTRA2: HtrA serine peptidase 2; IRGM: immunity related GTPase M; KD: knockdown; KDM6B: lysine demethylase 6B; KO: knockout; LAMP2: lysosomal associated membrane protein 2; LAP: LC3-associated phagocytosis; LDs: lipid droplets; Li KO: liver-specific knockout; LSECs: liver sinusoidal endothelial cells; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MAP3K5: mitogen-activated protein kinase kinase kinase 5; MED1: mediator complex subunit 1; MTOR: mechanistic target of rapamycin kinase; MTORC1: mechanistic target of rapamycin complex 1; NAFLD: non-alcoholic fatty liver disease; NASH: non-alcoholic steatohepatitis; NFE2L2: NFE2 like bZIP transcription factor 2; NOS3: nitric oxide synthase 3; NR1H3: nuclear receptor subfamily 1 group H member 3; OA: oleic acid; OE: overexpression; OSBPL8: oxysterol binding protein like 8; PA: palmitic acid; RUBCNL: rubicon like autophagy enhancer; PLIN2: perilipin 2; PLIN3: perilipin 3; PPARA: peroxisome proliferator activated receptor alpha; PRKAA2/AMPK: protein kinase AMP-activated catalytic subunit alpha 2; RAB: member RAS oncogene family; RPTOR: regulatory associated protein of MTOR complex 1; SCD: stearoyl-CoA desaturase; SIRT1: sirtuin 1; SIRT3: sirtuin 3; SNARE: soluble N-ethylmaleimide-sensitive factor attachment protein receptor; SQSTM1/p62: sequestosome 1; SREBF1: sterol regulatory element binding transcription factor 1;SREBF2: sterol regulatory element binding transcription factor 2; STING1: stimulator of interferon response cGAMP interactor 1; STX17: syntaxin 17; TAGs: triacylglycerols; TFEB: transcription factor EB; TP53/p53: tumor protein p53; ULK1: unc-51 like autophagy activating kinase 1; VMP1: vacuole membrane protein 1.

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来源期刊

Autophagy 生物-细胞生物学

CiteScore

21.30

自引率

2.30%

发文量

277

审稿时长

1 months

期刊介绍： Autophagy is a peer-reviewed journal that publishes research on autophagic processes, including the lysosome/vacuole dependent degradation of intracellular material. It aims to be the premier journal in the field and covers various connections between autophagy and human health and disease, such as cancer, neurodegeneration, aging, diabetes, myopathies, and heart disease. Autophagy is interested in all experimental systems, from yeast to human. Suggestions for specialized topics are welcome. The journal accepts the following types of articles: Original research, Reviews, Technical papers, Brief Reports, Addenda, Letters to the Editor, Commentaries and Views, and Articles on science and art. Autophagy is abstracted/indexed in Adis International Ltd (Reactions Weekly), EBSCOhost (Biological Abstracts), Elsevier BV (EMBASE and Scopus), PubMed, Biological Abstracts, Science Citation Index Expanded, Web of Science, and MEDLINE.