秘鲁不同海拔高度慢性肾脏病患者的血红蛋白水平。

IF 1.6 4区 医学 Q4 BIOPHYSICS High altitude medicine & biology Pub Date : 2023-09-01 Epub Date: 2023-06-13 DOI:10.1089/ham.2023.0046
Abdías Hurtado-Aréstegui, Karina Rosales-Mendoza, Yanissa Venegas-Justiniano, José Gonzales-Polar, Rina Barreto-Jara, Alaciel Melissa Palacios-Guillén
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引用次数: 0

摘要

Hurtado Aréstegui、Abdías、Karina Rosales Mendoza、Yanissa Venegas Justiniano、JoséGonzales Polar、Rina Barreto Jara和Alaciel Melissa Palacios Guillén。秘鲁不同海拔地区慢性肾脏病患者的血红蛋白水平。High Alt-Med Biol.24:2009-2132023。背景:血红蛋白降低是慢性肾脏疾病(CKD)的一种表现,居住在高海拔地区的人通过增加血红蛋白来适应缺氧。该研究的目的是确定海拔高度和相关因素对未接受透析(ND)的CKD患者血红蛋白水平的影响。方法:这项探索性和横断面研究在秘鲁的三个城市进行,这些城市位于不同的海拔高度:(1)“海平面”(161 m) ,(2)“中等海拔”(2335 m) ,和“高海拔”(3399 m) 。该研究包括20至90岁的CKD 3a期至5期的女性和男性。结果:在评估的256名志愿者中,92人生活在海平面,82人生活在中等海拔,82人居住在高海拔。三组患者的年龄、CKD各阶段的志愿者人数、收缩压和舒张压相似。血红蛋白水平因性别而异(p = 0.024)、CKD分期和海拔高度(p p 结论:生活在高海拔地区的CKD 3至5期ND患者的血红蛋白水平高于生活在中等海拔和海平面的患者。
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Hemoglobin Levels in Peruvian Patients with Chronic Kidney Disease at Different Altitudes.

Hurtado-Aréstegui, Abdías, Karina Rosales-Mendoza, Yanissa Venegas-Justiniano, José Gonzales-Polar, Rina Barreto-Jara, and Alaciel Melissa Palacios-Guillén. Hemoglobin levels in Peruvian patients with chronic kidney disease at different altitudes. High Alt Med Biol. 24:209-213, 2023. Background: Decreased hemoglobin is a manifestation of chronic kidney disease (CKD), and people who reside at high altitude adapt to hypoxia by increasing their hemoglobin. The study's objective was to determine the influence of altitude and the associated factors on the hemoglobin levels of patients with CKD who were not on dialysis (ND). Methods: This exploratory and cross-sectional study was carried out in three Peruvian cities, located at different altitudes: (1) "sea level" (161 m), (2) "moderate altitude" (2,335 m), and "high altitude" (3,399 m). The study included female and male individuals between 20 and 90 years old, with CKD stage 3a, through stage 5. Results: Of the 256 volunteers evaluated, 92 lived at sea level, 82 at moderate altitude, and 82 at high altitude. The three groups were similar in age, number of volunteers in each CKD stage, systolic blood pressure, and diastolic blood pressure. Hemoglobin levels were statistically different according to gender (p = 0.024), CKD stage, and altitude (p < 0.001). High-altitude dwellers had higher hemoglobin by 2.5 g/dl (95% confidence interval: 1.8-3.1, p < 0.001) than those living at lower altitudes (adjusted for gender, age, nutritional status, and smoking habit). For all CKD stages, the high-altitude population had higher hemoglobin levels than population at moderate altitude and at sea level. Conclusion: Subjects living at high altitude with CKD stages 3 to 5 who are yet ND have higher hemoglobin levels than those who live at moderate altitude and at sea level.

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来源期刊
High altitude medicine & biology
High altitude medicine & biology 医学-公共卫生、环境卫生与职业卫生
CiteScore
3.80
自引率
9.50%
发文量
44
审稿时长
>12 weeks
期刊介绍: High Altitude Medicine & Biology is the only peer-reviewed journal covering the medical and biological issues that impact human life at high altitudes. The Journal delivers critical findings on the impact of high altitude on lung and heart disease, appetite and weight loss, pulmonary and cerebral edema, hypertension, dehydration, infertility, and other diseases. It covers the full spectrum of high altitude life sciences from pathology to human and animal ecology.
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