大肠杆菌相关结肠癌癌症中的自噬：探讨其在减少IBD相关CAC发生和预防中的潜在作用。

IF 14.6 1区生物学 Q1 CELL BIOLOGY Autophagy Pub Date : 2024-02-01 Epub Date: 2024-01-25 DOI:10.1080/15548627.2023.2259214

Xuanhong Jin, Liangkun You, Jincheng Qiao, Weidong Han, Hongming Pan

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引用次数: 0

摘要

缩写：A.muciniphila：Akkermansia muciniphilla；AIEC：粘附性侵袭性大肠杆菌；AOM/DSS：偶氮甲烷葡聚糖硫酸钠；ATG：自噬相关；BECN1:beclin1，自噬相关；CAC：大肠杆菌相关结肠癌；CCDC50：包含50的线圈域；CLDN2：claudin 2；CoPEC：产大肠杆菌素的大肠杆菌；结直肠癌：癌症；DAMP：与危险/损害相关的分子模式；DC：树突状细胞；DSS：葡聚糖硫酸钠；DTP：耐药持久性；ER：内质网；ERN1/IRE1α：内质网-细胞核信号传导1；IBD：炎症性肠病；IECs：肠上皮细胞；IKK:IkappaB激酶；IL：白细胞介素；IRGM1：免疫相关GTP酶家族M成员1；ISC：肠干细胞；LPS：脂多糖；MAP1LC3/LC3：微管相关蛋白1轻链3；MAPK：丝裂原活化蛋白激酶；MDP：壁酰二肽；MELK：母体胚胎亮氨酸拉链激酶；MHC：主要组织相容性复合体；miRNA：微小RNA；MTOR：雷帕霉素激酶的机制靶点；NLRP3:NLR家族，pyrin结构域包含3个；NOD2：包含2的核苷酸结合寡聚化结构域；NRBF2：核受体结合因子2；PAMPs:病原体相关分子模式；PI3K：I类磷酸肌醇3-激酶；PtdIns3K：III类磷脂酰肌醇3-激酶；PYCARD/ASC：包含PYD和CARD域；RALGAPA2/RalGAPα2:Ral GTP酶激活蛋白，α亚基2（催化）；RIPK2/CARD3：受体（TNFRSF）相互作用的丝氨酸-苏氨酸激酶2；RIPK3：受体相互作用丝氨酸-苏氨酸激酶3；ROS：活性氧；sCRC：散发性癌症；SMARCA4/BRG1:SWI/SNF相关，基质相关，染色质肌动蛋白依赖性调节因子，亚家族a，成员4；SQSTM1：螯合体1；STAT3：信号转导子和转录激活子3；TNF/TNFA：肿瘤坏死因子；ULK1:unc-51样自噬激活激酶1；UPR：未折叠蛋白反应；野生型。

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Autophagy in colitis-associated colon cancer: exploring its potential role in reducing initiation and preventing IBD-Related CAC development.

Abbreviations: A. muciniphila: Akkermansia muciniphila; AIEC: adherent invasive Escherichia coli; AOM/DSS: azoxymethane-dextran sodium sulfate; ATG: autophagy related; BECN1: beclin1, autophagy related; CAC: colitis-associated colon cancer; CCDC50: coiled-coil domain containing 50; CLDN2: claudin 2; CoPEC: colibactin-producing Escherichia coli; CRC: colorectal cancer; DAMPs: danger/damage-associated molecular patterns; DC: dendritic cell; DSS: dextran sulfate sodium; DTP: drug-resistant persistent; ER: endoplasmic reticulum; ERN1/IRE1α: endoplasmic reticulum to nucleus signaling 1; IBD: inflammatory bowel disease; IECs: intestinal epithelial cells; IKK: IkappaB kinase; IL: interleukin; IRGM1: immunity-related GTPase family M member 1; ISC: intestinal stem cell; LPS: lipopolysaccharide; MAP1LC3/LC3: microtubule-associated protein 1 light chain 3; MAPK: mitogen-activated protein kinase; MDP: muramyl dipeptide; MELK: maternal embryonic leucine zipper kinase; MHC: major histocompatibility complex; miRNA: microRNA; MTOR: mechanistic target of rapamycin kinase; NLRP3: NLR family, pyrin domain containing 3; NOD2: nucleotide-binding oligomerization domain containing 2; NRBF2: nuclear receptor binding factor 2; PAMPs: pathogen-associated molecular patterns; PI3K: class I phosphoinositide 3-kinase; PtdIns3K: class III phosphatidylinositol 3-kinase; PYCARD/ASC: PYD and CARD domain containing; RALGAPA2/RalGAPα2: Ral GTPase activating protein protein, alpha subunit 2 (catalytic); RIPK2/CARD3: receptor (TNFRSF)-interacting serine-threonine kinase 2; RIPK3: receptor-interacting serine-threonine kinase 3; ROS: reactive oxygen species; sCRC: sporadic colorectal cancer; SMARCA4/BRG1: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4; SQSTM1: sequestosome 1; STAT3: signal transducer and activator of transcription 3; TNF/TNFA: tumor necrosis factor; ULK1: unc-51 like autophagy activating kinase 1; UPR: unfolded protein response; WT: wild-type.

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来源期刊

Autophagy 生物-细胞生物学

CiteScore

21.30

自引率

2.30%

发文量

277

审稿时长

1 months

期刊介绍： Autophagy is a peer-reviewed journal that publishes research on autophagic processes, including the lysosome/vacuole dependent degradation of intracellular material. It aims to be the premier journal in the field and covers various connections between autophagy and human health and disease, such as cancer, neurodegeneration, aging, diabetes, myopathies, and heart disease. Autophagy is interested in all experimental systems, from yeast to human. Suggestions for specialized topics are welcome. The journal accepts the following types of articles: Original research, Reviews, Technical papers, Brief Reports, Addenda, Letters to the Editor, Commentaries and Views, and Articles on science and art. Autophagy is abstracted/indexed in Adis International Ltd (Reactions Weekly), EBSCOhost (Biological Abstracts), Elsevier BV (EMBASE and Scopus), PubMed, Biological Abstracts, Science Citation Index Expanded, Web of Science, and MEDLINE.