中和和增强针对SARS-CoV-2的抗体。

IF 5 3区医学 Q2 IMMUNOLOGY Inflammation and Regeneration Pub Date : 2022-12-05 DOI:10.1186/s41232-022-00233-7

Yafei Liu, Hisashi Arase

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引用次数: 3

摘要

2019年以来，SARS-CoV-2的高传播性和全球快速传播给全球医疗保健带来了巨大负担。抗sars - cov -2中和抗体不仅在防止感染方面发挥重要作用，而且在清除病毒方面发挥重要作用，对于提供长期免疫至关重要。另一方面，针对病毒的抗体并不总是具有保护作用。随着SARS-CoV-2免疫逃逸变异的出现，疫苗设计策略以及抗体介导的治疗方法变得更加重要。本文从基础研究和临床应用两方面综述了SARS-CoV-2抗体的研究进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Neutralizing and enhancing antibodies against SARS-CoV-2.

The high transmissibility and rapid global spread of SARS-CoV-2 since 2019 has led to a huge burden on healthcare worldwide. Anti-SARS-CoV-2 neutralizing antibodies play an important role in not only protecting against infection but also in clearing the virus and are essential to providing long-term immunity. On the other hand, antibodies against the virus are not always protective. With the emergence of SARS-CoV-2 immune escape variants, vaccine design strategies as well as antibody-mediated therapeutic approaches have become more important. We review some of the findings on SARS-CoV-2 antibodies, focusing on both basic research and clinical applications.

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来源期刊

Inflammation and Regeneration Multiple-

CiteScore

11.10

自引率

1.20%

发文量

审稿时长

11 weeks

期刊介绍： Inflammation and Regeneration is the official journal of the Japanese Society of Inflammation and Regeneration (JSIR). This journal provides an open access forum which covers a wide range of scientific topics in the basic and clinical researches on inflammation and regenerative medicine. It also covers investigations of infectious diseases, including COVID-19 and other emerging infectious diseases, which involve the inflammatory responses. Inflammation and Regeneration publishes papers in the following categories: research article, note, rapid communication, case report, review and clinical drug evaluation.