动态核极化固体核磁共振监测添加剂对甘氨酸结晶过程的影响

IF 1.8 3区 化学 Q4 CHEMISTRY, PHYSICAL Solid state nuclear magnetic resonance Pub Date : 2022-12-01 DOI:10.1016/j.ssnmr.2022.101836
Marie Juramy , Paolo Cerreia Vioglio , Fabio Ziarelli , Stéphane Viel , Pierre Thureau , Giulia Mollica
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引用次数: 1

摘要

结晶是许多领域的基础,研究结晶时间对固相序列的影响是理解和控制结晶过程的关键。在此,我们使用固态核磁共振策略来监测甘氨酸的结晶过程,甘氨酸是一种多态模型化合物,在结晶添加剂(如甲醇或氯化钠)的影响下。更具体地说,我们的策略是基于低温和动态核极化(DNP)的结合来捕获和检测瞬态结晶形式,这可能只存在于少量。有趣的是,我们的结果表明,即使在结晶溶液中没有甘油,这些添加剂也能产生有价值的DNP信号增强。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Monitoring the influence of additives on the crystallization processes of glycine with dynamic nuclear polarization solid-state NMR

Crystallization is fundamental in many domains, and the investigation of the sequence of solid phases produced as a function of crystallization time is thus key to understand and control crystallization processes. Here, we used a solid-state nuclear magnetic resonance strategy to monitor the crystallization process of glycine, which is a model compound in polymorphism, under the influence of crystallizing additives, such as methanol or sodium chloride. More specifically, our strategy is based on a combination of low-temperatures and dynamic nuclear polarization (DNP) to trap and detect transient crystallizing forms, which may be present only in low quantities. Interestingly, our results show that these additives yield valuable DNP signal enhancements even in the absence of glycerol within the crystallizing solution.

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来源期刊
CiteScore
5.30
自引率
9.40%
发文量
42
审稿时长
72 days
期刊介绍: The journal Solid State Nuclear Magnetic Resonance publishes original manuscripts of high scientific quality dealing with all experimental and theoretical aspects of solid state NMR. This includes advances in instrumentation, development of new experimental techniques and methodology, new theoretical insights, new data processing and simulation methods, and original applications of established or novel methods to scientific problems.
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