血糖控制是2型糖尿病患者血清VEGF水平的主要决定因素。

IF 1.6 Q2 MEDICINE, GENERAL & INTERNAL Romanian Journal of Internal Medicine Pub Date : 2023-09-01 DOI:10.2478/rjim-2023-0009
Liong Boy Kurniawan, Rika Andriany, Yuyun Widaningsih, Tenri Esa, Uleng Bahrun, Endy Adnan, Mansyur Arif
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引用次数: 0

摘要

介绍。糖尿病(DM)是一种主要的内分泌疾病,随着病情的发展可引起血管并发症。血管内皮生长因子(VEGF)与糖尿病微血管和大血管并发症的发生有关。本研究旨在评估可能导致2型糖尿病患者血清VEGF水平升高的几个因素,包括血压、体重指数、血脂、肾功能和血糖控制。方法。本横断面研究在65例2型糖尿病患者中进行。测量收缩期、舒张期、平均动脉压(MAP)和体重指数(BMI)。采用酶联免疫吸附法(ELISA)检测血清VEGF水平,采用胶乳凝集抑制试验检测血红蛋白A1c (HbA1c)水平,酶光度法检测血清葡萄糖、血脂、尿素和肌酐水平。结果。血清VEGF水平与BMI (p = 0.001, r = 0.397)、空腹血糖(FPG) (p = 0.001, r = 0.418)、HbA1c (p < 0.001, r = 0.600)、收缩期(p = 0.001), r = 0.397)、舒张期(p = 0.021, r = 0.286)、MAP (p = 0.001, r = 0.001)有显著相关性。进一步多因素线性回归分析显示,HbA1c对数(log)是VEGF水平的决定因素(p < 0.001, β = 0.631,调整后R2 = 38.9%)。HbA1c是2型糖尿病患者血清VEGF水平的主要决定因素。
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Glycemic control as the main determinant factor of serum VEGF levels in type 2 diabetes mellitus patients.

Introduction. Diabetes mellitus (DM) is a main endocrine disorder that may cause vascular complications as the disease progresses. Vascular endothelial growth factor (VEGF) has been linked to the development of micro and macrovascular diabetic complications. This study aimed to assess several factors including blood pressure, body mass index, lipid profile, kidney function, and glycemic control that may provide the rise of serum VEGF levels in type 2 DM subjects. Methods. This cross-sectional study was carried out among 65 type 2 DM subjects. Systole, diastole, mean arterial pressure (MAP), and body mass index (BMI) were measured. The levels of serum VEGF were measured by Enzyme-linked immunosorbent assay (ELISA), Hemoglobin A1c (HbA1c) levels were measured by latex agglutination inhibition test, while serum glucose, lipid profiles, urea, and creatinine levels were tested by enzymatic photometric method. Results. The levels of serum VEGF had a significant correlation with BMI (p = 0.001, r = 0.397), fasting plasma glucose (FPG) (p = 0.001, r = 0.418), HbA1c (p < 0.001, r = 0.600), systole (p = 0.001), r = 0.397), diastole (p = 0.021, r = 0.286), and MAP (p = 0.001, r = 0.001). Further multivariate linear regression analysis revealed that HbA1c logarithm (log) was the determinant factor of VEGF levels (p < 0.001, β = 0.631, Adjusted R2 = 38.9%) Conclusion. HbA1c is the main determinant factor of serum VEGF levels among type 2 DM patients.

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来源期刊
Romanian Journal of Internal Medicine
Romanian Journal of Internal Medicine MEDICINE, GENERAL & INTERNAL-
CiteScore
3.20
自引率
5.30%
发文量
35
审稿时长
15 weeks
期刊介绍: Romanian Journal of Physics is a journal publishing physics contributions on the following themes: •Theoretical Physics & Applied Mathematics •Nuclear Physics •Solid State Physics & Materials Science •Statistical Physics & Quantum Mechanics •Optics •Spectroscopy •Plasma & Lasers •Nuclear & Elementary Particles Physics •Atomic and Molecular Physics •Astrophysics •Atmosphere and Earth Science •Environment Protection
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