螺内酯对非酒精性脂肪肝药物治疗的影响。

IF 2.5 Q3 ENDOCRINOLOGY & METABOLISM Minerva endocrinology Pub Date : 2023-09-01 Epub Date: 2021-10-20 DOI:10.23736/S2724-6507.21.03564-8
Apostolis Papaefthymiou, Michael Doulberis, Kyriaki Karafyllidou, Eleftherios Chatzimichael, Georgia Deretzi, Aristomenis K Exadaktylos, Fotios Sampsonas, Athanasios Gelasakis, Spyros I Papamichos, Georgios Kotronis, Dimitra Gialamprinou, Elisabeth Vardaka, Stergios A Polyzos, Jannis Kountouras
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引用次数: 3

摘要

非酒精性脂肪肝(NAFLD)最近被重命名为代谢(功能障碍)相关脂肪肝(MAFLD),以更好地描述其病因。至少在西方社会,NAFLD是一种潜在的流行病,患病率不断上升。其多因素发病机制已被部分阐明,迄今为止还没有批准的NAFLD药物治疗方法。临床试验中研究了大量不同的选择,针对不同的途径和分子。由于盐皮质激素受体(MR)和肾素-血管紧张素-醛固酮系统(RAAS)似乎与NAFLD有关,在这篇简要的综述中,我们将重点关注一种相当经典且廉价的药物,螺内酯。我们介绍了目前MR和RAAS相关临床前模型和人体试验的证据,这些模型和试验报告了与NAFLD的相关性。总之,关于RAAS的螺内酯的证据被评论为NAFLD潜在的未来药理学治疗。
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Effect of spironolactone on pharmacological treatment of nonalcoholic fatty liver disease.

Nonalcoholic fatty liver disease (NAFLD) was recently renamed to metabolic (dysfunction)-associated fatty liver disease (MAFLD) to better characterize its pathogenic origin. NAFLD represents, at least in western societies, a potential epidemic with raising prevalence. Its multifactorial pathogenesis is partially unraveled and till now there is no approved pharmacotherapy for NAFLD. A plethora of various choices are investigated in clinical trials, targeting an arsenal of different pathways and molecules. Since the mineralocorticoid receptor (MR) and renin-angiotensin-aldosterone system (RAAS) appear to be implicated in NAFLD, within this concise review, we focus on a rather classical and inexpensive pharmacological agent, spironolactone. We present the current lines of evidence of MR and RAAS-related preclinical models and human trials reporting an association with NAFLD. In conclusion, evidence about spironolactone of RAAS is commented, as potential future pharmacological management of NAFLD.

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