《纪元2021》:未来十年有哪些抗病毒药物?

4区 化学 Q3 Chemistry Annual Reports in Medicinal Chemistry Pub Date : 2021-01-01 DOI:10.1016/bs.armc.2021.09.004
Elisabetta Groaz, Erik De Clercq, Piet Herdewijn
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引用次数: 6

摘要

尽管抗病毒药物的发展取得了相当大的进展,其中抗免疫缺陷病毒(HIV)和抗丙型肝炎病毒(HCV)药物可以被认为是真正的成功案例,但许多病毒感染仍然没有有效的治疗方法。这不仅适用于最近蔓延到人类的人畜共患病毒(如严重急性呼吸综合征冠状病毒2型(SARS-CoV-2))引起的传染病暴发,也适用于通过接种疫苗得到控制的古老病毒性疾病,如天花、脊髓灰质炎、麻疹和狂犬病。由流感、呼吸道合胞病毒(RSV)和鼻病毒引起的地方性呼吸道感染是一个基本上未解决的问题,其相关发病率可能会随着空气污染的增加而恶化。此外,气候变化将使工业化国家面临病毒性出血热死灰复燃的危险,这也可能成为全球性传染病。在此,我们总结了最近在寻找新的抗病毒药物方面取得的进展,以对抗世界人口在未来十年中将日益频繁地面对的这些不同威胁。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Anno 2021: Which antivirals for the coming decade?

Despite considerable progress in the development of antiviral drugs, among which anti-immunodeficiency virus (HIV) and anti-hepatitis C virus (HCV) medications can be considered real success stories, many viral infections remain without an effective treatment. This not only applies to infectious outbreaks caused by zoonotic viruses that have recently spilled over into humans such as severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), but also ancient viral diseases that have been brought under control by vaccination such as variola (smallpox), poliomyelitis, measles, and rabies. A largely unsolved problem are endemic respiratory infections due to influenza, respiratory syncytial virus (RSV), and rhinoviruses, whose associated morbidity will likely worsen with increasing air pollution. Furthermore, climate changes will expose industrialized countries to a dangerous resurgence of viral hemorrhagic fevers, which might also become global infections. Herein, we summarize the recent progress that has been made in the search for new antivirals against these different threats that the world population will need to confront with increasing frequency in the next decade.

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来源期刊
CiteScore
5.70
自引率
0.00%
发文量
0
审稿时长
>12 weeks
期刊介绍: Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry with an emphasis on emerging topics in the biological sciences that are expected to provide the basis for entirely new future therapies.
期刊最新文献
The challenges and opportunities of developing small molecule inhibitors of MraY. Preface Anno 2021: Which antivirals for the coming decade? Improving properties of the nucleobase analogs T-705/T-1105 as potential antiviral. Broad spectrum antiviral nucleosides-Our best hope for the future.
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