韩国hiv感染者中与进行性多灶性脑白质病相关的癫痫发作

IF 2.3 4区医学 Q3 NEUROSCIENCES Journal of NeuroVirology Pub Date : 2023-06-01 DOI:10.1007/s13365-023-01136-0

Hyun Kyung Kim, Ji Yun Kang, Seo-Young Lee

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引用次数: 0

摘要

我们调查了韩国HIV感染患者进行性多灶性白质脑病(PML)相关癫痫发作的发生率和危险因素。在34例患者中，14例(41.2%)在82个月的中位随访期间发生癫痫发作。从PML诊断到癫痫发作的中位时间为44个月，范围为0 ~ 133个月。癫痫发作的PML患者在脑MRI上更常出现认知障碍和多发或弥漫性病变。这些发现强调了hiv感染的PML患者在疾病的任何阶段，特别是在广泛涉及的病例中，癫痫发作的风险增加。

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Epileptic seizures associated with progressive multifocal leukoencephalopathy in HIV-infected patients in Korea.

We investigated the incidence and risk factors of seizures related to progressive multifocal leukoencephalopathy (PML) in Korean patients infected with HIV. Of the 34 patients, 14 (41.2%) developed epileptic seizures during a median follow-up of 82 months. The median time from PML diagnosis to seizure onset was 44 months, ranging from 0 to 133 months. Patients with PML who developed seizures more commonly had cognitive impairment and multiple or diffuse lesions on brain MRI. These findings highlight the increased seizure risk among HIV-infected patients with PML at any stage of the disease, particularly in cases with extensive involvement.

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来源期刊

Journal of NeuroVirology 医学-病毒学

CiteScore

6.60

自引率

3.10%

发文量

审稿时长

6-12 weeks

期刊介绍： The Journal of NeuroVirology (JNV) provides a unique platform for the publication of high-quality basic science and clinical studies on the molecular biology and pathogenesis of viral infections of the nervous system, and for reporting on the development of novel therapeutic strategies using neurotropic viral vectors. The Journal also emphasizes publication of non-viral infections that affect the central nervous system. The Journal publishes original research articles, reviews, case reports, coverage of various scientific meetings, along with supplements and special issues on selected subjects. The Journal is currently accepting submissions of original work from the following basic and clinical research areas: Aging & Neurodegeneration, Apoptosis, CNS Signal Transduction, Emerging CNS Infections, Molecular Virology, Neural-Immune Interaction, Novel Diagnostics, Novel Therapeutics, Stem Cell Biology, Transmissable Encephalopathies/Prion, Vaccine Development, Viral Genomics, Viral Neurooncology, Viral Neurochemistry, Viral Neuroimmunology, Viral Neuropharmacology.