个性化医疗中转化基因组学的不同观点

Berkcan Doğan, Hale Göksever Çelik, Reyhan Diz Küçükkaya, Ece Gümüşoğlu Acar, Tuba Günel
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引用次数: 0

摘要

在医疗保健行业,个性化医疗是一个相对较新的、有趣的概念。当前研究中的新方法支持使用新技术工具基于个体的基因组、表观基因组和蛋白质组谱寻找生物标志物。这一观点涉及确定最佳医疗干预措施的潜力,并为治疗提供最佳的利益-风险平衡,同时也考虑到患者的个人情况。转化基因组学是个性化医学的一个分支,它通过促进临床或非临床筛查试验、告知诊断和治疗方法、定期提供个性化健康风险评估和个性化治疗,正在改变医疗实践。对转化基因组学的进一步研究将在创造治疗癌症、药物基因组学和妇女健康的新方法方面发挥关键作用。我们目前的知识可以用来开发新的解决方案,可以用来最小化、改善、管理和延迟疾病的症状,并保持健康的生活方式。在这篇综述中,我们定义和讨论了翻译基因组学在一些特殊领域的现状,包括整合到研究和医疗保健中。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Different perspectives on translational genomics in personalized medicine

Personalized medicine is a relatively new and interesting concept in the medical and healthcare industries. New approaches in current research have supported the search for biomarkers, based on the genomic, epigenomic and proteomic profile of individuals, using new technological tools. This perspective involves the potential to determine optimal medical interventions and provide the optimal benefit-risk balance for treatment, whilst it also takes a patient's personal situation into consideration. Translational genomics, a subfield of personalized medicine, is changing medical practice, by facilitating clinical or non-clinical screening tests, informing diagnoses and therapeutics, and routinely offering personalized health-risk assessments and personalized treatments. Further research into translational genomics will play a critical role in creating a new approach to cancer, pharmacogenomics, and women's health. Our current knowledge may be used to develop new solutions that can be used to minimize, improve, manage, and delay the symptoms of diseases in real-time and maintain a healthy lifestyle. In this review, we define and discuss the current status of translational genomics in some special areas including integration into research and health care.

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来源期刊
CiteScore
2.40
自引率
7.10%
发文量
56
期刊介绍: Journal of the Turkish-German Gynecological Association is the official, open access publication of the Turkish-German Gynecological Education and Research Foundation and Turkish-German Gynecological Association and is published quarterly on March, June, September and December. It is an independent peer-reviewed international journal printed in English language. Manuscripts are reviewed in accordance with “double-blind peer review” process for both reviewers and authors. The target audience of Journal of the Turkish-German Gynecological Association includes gynecologists and primary care physicians interested in gynecology practice. It publishes original works on all aspects of obstertrics and gynecology. The aim of Journal of the Turkish-German Gynecological Association is to publish high quality original research articles. In addition to research articles, reviews, editorials, letters to the editor, diagnostic puzzle are also published. Suggestions for new books are also welcomed. Journal of the Turkish-German Gynecological Association does not charge any fee for article submission or processing.
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