硫化氢反应性光治疗剂:设计策略和生物学应用

IF 3.8 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY ACS Bio & Med Chem Au Pub Date : 2023-06-23 DOI:10.1021/acsbiomedchemau.3c00028
Musa Dirak, Sarp E. Turan and Safacan Kolemen*, 
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引用次数: 0

摘要

硫化氢(H2S)是一种重要的气体递质,在正常的生理过程中发挥着重要作用,尤其是在重要的信号通路中。然而,内源性H2S浓度的波动可能与严重的健康问题有关,如神经退行性疾病、癌症、糖尿病、炎症、心血管疾病和高血压。因此,它在治疗应用中,特别是在光疗领域引起了极大的关注。光动力疗法(PDT)和光热疗法(PTT)是光疗的两个亚类,它们利用活性氧(ROS)或光敏剂(PS)照射后的局部温度升高来实现治疗作用。与传统方法相比,光疗法具有独特的优势;因此,它们非常有前途和受欢迎。新一代PS遵循的设计原则之一是构建基于活动的PS,它在被疾病相关刺激激活之前保持不活动状态。这些可激活的PS显著提高了治疗的选择性和疗效。在这篇综述中,我们总结了基于小分子和纳米材料的PDT和PTT试剂,它们被H2S选择性激活以启动其细胞毒性作用。我们结合了单模PDT和PTT药物,以及可以结合多种治疗方法的协同和/或多模式光敏剂。此外,强调了同时提供治疗和成像的H2S反应性治疗剂。详细讨论了每个例子的设计方法、工作原理和生物学应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Hydrogen Sulfide Responsive Phototherapy Agents: Design Strategies and Biological Applications

Hydrogen sulfide (H2S) is one of the critical gasotransmitters, which play important roles in regular physiological processes, especially in vital signaling pathways. However, fluctuations in endogenous H2S concentration can be linked to serious health problems, such as neurodegenerative diseases, cancer, diabetes, inflammation, cardiovascular diseases, and hypertension. Thus, it has attracted a great deal of attention in therapeutic applications, specifically in the field of phototherapy. Photodynamic therapy (PDT) and photothermal therapy (PTT) are two subclasses of phototherapy, which utilize either reactive oxygen species (ROS) or local temperature increase upon irradiation of a photosensitizer (PS) to realize the therapeutic action. Phototherapies offer unique advantages compared to conventional methods; thus, they are highly promising and popular. One of the design principles followed in new generation PSs is to build activity-based PSs, which stay inactive before getting activated by disease-associated stimuli. These activatable PSs dramatically improve the selectivity and efficacy of the therapy. In this review, we summarize small molecule and nanomaterial-based PDT and PTT agents that are activated selectively by H2S to initiate their cytotoxic effect. We incorporate single mode PDT and PTT agents along with synergistic and/or multimodal photosensitizers that can combine more than one therapeutic approach. Additionally, H2S-responsive theranostic agents, which offer therapy and imaging at the same time, are highlighted. Design approaches, working principles, and biological applications for each example are discussed in detail.

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来源期刊
ACS Bio & Med Chem Au
ACS Bio & Med Chem Au 药物、生物、化学-
CiteScore
4.10
自引率
0.00%
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0
期刊介绍: ACS Bio & Med Chem Au is a broad scope open access journal which publishes short letters comprehensive articles reviews and perspectives in all aspects of biological and medicinal chemistry. Studies providing fundamental insights or describing novel syntheses as well as clinical or other applications-based work are welcomed.This broad scope includes experimental and theoretical studies on the chemical physical mechanistic and/or structural basis of biological or cell function in all domains of life. It encompasses the fields of chemical biology synthetic biology disease biology cell biology agriculture and food natural products research nucleic acid biology neuroscience structural biology and biophysics.The journal publishes studies that pertain to a broad range of medicinal chemistry including compound design and optimization biological evaluation molecular mechanistic understanding of drug delivery and drug delivery systems imaging agents and pharmacology and translational science of both small and large bioactive molecules. Novel computational cheminformatics and structural studies for the identification (or structure-activity relationship analysis) of bioactive molecules ligands and their targets are also welcome. The journal will consider computational studies applying established computational methods but only in combination with novel and original experimental data (e.g. in cases where new compounds have been designed and tested).Also included in the scope of the journal are articles relating to infectious diseases research on pathogens host-pathogen interactions therapeutics diagnostics vaccines drug-delivery systems and other biomedical technology development pertaining to infectious diseases.
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