[2016-2018年北京市学龄儿童维生素D状况及分布]。

Yimei Sha, Liyu Huang, Ruixuan Wang, Bo Yu, Yihong Yao, Yingjie Yu, Yao Zhao
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引用次数: 0

摘要

目的:了解北京市学龄儿童维生素D的营养状况。方法:该数据为《2016-2017年中国儿童及哺乳母亲营养与健康监测》北京市监测数据的一部分。共招募了来自10所小学、10所初中和5所高中的1385名学生。采用电化学发光免疫分析法测定血清维生素D浓度。进一步描述了学龄儿童血清维生素D在不同地区、年龄、体重指数(BMI)、腰围、户外活动时间和近视情况下的分布。比较不同亚组中维生素D不足和缺乏的发生率。结果:6-11岁和12-17岁学生血清25(OH)D_3 [M(P25, P75)]的中位浓度分别为20.86(16.48,25.31)ng/mL和14.12(11.04,19.17)ng/mL。男性学龄儿童血清25(OH)D_3高于女性。12 ~ 17岁学生血清25(OH)D_3低于6 ~ 11岁学生。城市学生血清25(OH)D_3低于农村学生,近视学生血清25(OH)D_3低于非近视学生(P<0.01)。血清25(OH)D_3在户外活动时间≥2小时的学生与小于2小时的学生、正常体重与超重肥胖学生、正常腰腹肥胖学生之间无显著差异。学龄儿童维生素D缺乏率为18.8%(261人),维生素D不足率为40.1%(556人),维生素D不足率为59.0%(817人)。女生维生素D缺乏症较男生严重,12-17岁学生维生素D不足和缺乏症较6-11岁学生严重。城市学生维生素D缺乏情况较农村严重,近视学生维生素D缺乏情况较非近视学生严重(P<0.01)。户外活动时间大于或等于2小时的学生与小于2小时的学生、正常体重与超重肥胖学生、正常腰腹肥胖学生的维生素D缺乏症无显著差异。将有统计学意义的变量(性别、年龄、地区、户外活动时间、超重、肥胖、腹型肥胖、近视)纳入多元Logistic回归模型进行分析。结果显示,女孩(OR= 2.005, P<0.001)、12-17岁(OR=4.310, P<0.001)、农村(OR=0.586, P<0.001)维生素D缺乏和不足的发生率较高。结论:北京市学生维生素D状况不理想,女生维生素D缺乏和不足情况较男生严重;12-17岁儿童维生素D缺乏和不足较6-11岁儿童更为严重;城市学生维生素D缺乏症较农村学生更为严重。
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[Vitamin D status and distribution in Beijing school aged children in 2016-2018].

Objective: To evaluate the nutritional status of vitamin D in school-age children in Beijing.

Methods: The data was part of the monitoring data of Beijing in "Chinese Nutrition and Health Monitoring of Children and Nursing Mothers 2016-2017". A total of 1385 students were recruited from 10 primary schools, 10 junior middle schools and 5 senior high schools. The concentrations of serum vitamin D were determined using electrochemiluminescence immunoassay. The distribution of serum vitamin D in school-age children was further described for different regions, age, body mass index(BMI), waistline, outdoor activity time and myopia. The prevalence of the insufficiency and deficiency of vitamin D was compared in different subgroups.

Results: The median concentration of serum 25(OH)D_3 [M(P25, P75)] of students aged 6-11 and 12-17 were 20.86(16.48, 25.31) ng/mL and 14.12(11.04, 19.17) ng/mL. The serum 25(OH)D_3 of male school-age children was higher than that of female. The serum 25(OH)D_3 of students aged 12-17 was lower than that of students aged 6-11. The serum 25(OH)D_3 of urban students was lower than that of rural students, and the serum 25(OH)D_3 of myopia students was lower than that of non-myopia students(P<0.01). There was no significant difference in serum 25(OH)D_3 between students with outdoor activity time greater than or equal to 2 hours and students with less than 2 hours, normal weight and overweight and obese students, normal waist and abdominal obesity students. The vitamin D deficiency rate, insufficiency rate, insufficiency and deficiency rate of school-age children were 18.8%(261), 40.1%(556) and 59.0%(817). The vitamin D deficiency in girls was more serious than that in boys, and the vitamin D insufficiency and deficiency of students aged 12-17 were more serious than that of students aged 6-11. The vitamin D deficiency of students in urban areas was more serious than that in rural areas, and the vitamin D deficiency of myopia students was more serious than that of non-myopia(P<0.01). There was no significant difference in vitamin D deficiency between students with outdoor activity time greater than or equal to 2 hours and students with less than 2 hours, normal weight and overweight and obese students, normal waist and abdominal obesity students. The statistically significant variables(gender, age, region, outdoor activity time, overweight, obesity, abdominal obesity and myopia) were included in the multivariate Logistic regression model for analysis. The result showed that girls(OR = 2.005, P<0.001), 12-17 years old(OR=4.310, P<0.001), rural(OR=0.586, P<0.001) with vitamin D deficiency and insufficiency were more likely.

Conclusion: The vitamin D status of students in Beijing is not ideal, and the deficiency and insufficiency of vitamin D in girls is more serious than that in boys; The deficiency and insufficiency of vitamin D in 12-17 years old is more serious than that in 6-11 years old; The vitamin D deficiency of urban students is more serious than that of rural students.

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