骨钙素一种多方面的骨源性激素

IF 12.6 2区 医学 Q1 NUTRITION & DIETETICS Annual review of nutrition Pub Date : 2023-08-21 DOI:10.1146/annurev-nutr-061121-091348
Gerard Karsenty
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引用次数: 0

摘要

功能缺失和功能增益实验共同发现,骨源性分泌分子骨钙素是一种激素,在啮齿动物和灵长类动物中具有广泛的影响。骨钙素与三种受体之一结合后,会对能量代谢、类固醇生成、神经递质生物合成等各个方面产生深远影响,进而影响男性生育能力、电解质平衡、认知、急性应激反应和运动能力。虽然这篇综述主要侧重于骨钙素对能量代谢的调节,但也涉及到骨钙素的其他功能。最后,它提出了骨钙素功能之间以及这些功能与骨骼结构功能之间的共同主题。
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Osteocalcin: A Multifaceted Bone-Derived Hormone.

Together, loss- and gain-of-function experiments have identified the bone-derived secreted molecule osteocalcin as a hormone with a broad reach in rodents and primates. Following its binding to one of three receptors, osteocalcin exerts a profound influence on various aspects of energy metabolism as well as steroidogenesis, neurotransmitter biosynthesis and thereby male fertility, electrolyte homeostasis, cognition, the acute stress response, and exercise capacity. Although this review focuses mostly on the regulation of energy metabolism by osteocalcin, it also touches on its other functions. Lastly, it proposes what could be a common theme between the functions of osteocalcin and between these functions and the structural functions of bone.

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来源期刊
Annual review of nutrition
Annual review of nutrition 医学-营养学
CiteScore
15.80
自引率
0.00%
发文量
19
期刊介绍: Annual Review of Nutrition Publication History:In publication since 1981 Scope:Covers significant developments in the field of nutrition Topics Covered Include: Energy metabolism; Carbohydrates; Lipids; Proteins and amino acids; Vitamins; Minerals; Nutrient transport and function; Metabolic regulation; Nutritional genomics; Molecular and cell biology; Clinical nutrition; Comparative nutrition; Nutritional anthropology; Nutritional toxicology; Nutritional microbiology; Epidemiology; Public health nutrition
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