18F-FP-CIT PET/CT可能为散发性克雅氏病1例，首发症状为帕金森病。

IF 1.9 3区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Prion Pub Date : 2022-12-01 DOI:10.1080/19336896.2022.2093078

Songhan Tang, Xiaofeng Dou, Ying Zhang

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引用次数: 1

摘要

克雅氏病(CJD)是一种低患病率、致死性神经退行性疾病。帕金森病作为CJD的首发症状是罕见的。我们提出一个病例表现入睡困难为非特异性前驱症状和帕金森氏症为初始症状。采用18 F-FP-CIT进行多巴胺转运体(DAT)正电子发射断层扫描(PET/CT)。dat扫描显示双侧后壳核突触前多巴胺能缺失，支持克雅氏病黑质纹状体通路功能障碍假说。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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18F-FP-CIT PET/CT in a case of probable sporadic Creutzfeldt-Jakob disease with parkinsonism as initial symptom.

Creutzfeldt-Jakob disease (CJD) is a low-prevalence, fatal neurodegenerative disease. Parkinsonism as first symptom of CJD is rare. We present a case manifesting difficulty falling asleep as unspecific prodromal symptom and parkinsonism as initial symptom. The patient received positron emission tomography/computed tomography (PET/CT) of dopamine transporter (DAT) using 18 F-FP-CIT. The DAT-scan demonstrated presynaptic dopaminergic deficit in bilateral posterior putamen, which supports the hypothesis of nigrostriatal pathway dysfunction in CJD.

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来源期刊

Prion 生物-生化与分子生物学

CiteScore

5.20

自引率

4.30%

发文量

审稿时长

6-12 weeks

期刊介绍： Prion is the first international peer-reviewed open access journal to focus exclusively on protein folding and misfolding, protein assembly disorders, protein-based and structural inheritance. The goal is to foster communication and rapid exchange of information through timely publication of important results using traditional as well as electronic formats. The overriding criteria for publication in Prion are originality, scientific merit and general interest.