干细胞和器官芯片:人类不孕症治疗的新技术。

IF 22 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM Endocrine reviews Pub Date : 2022-09-26 DOI:10.1210/endrev/bnab047
Eisa Tahmasbpour Marzouni, Catharyn Stern, Andrew Henrik Sinclair, Elena Jane Tucker
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引用次数: 2

摘要

对于大多数生育失败或性腺发育不良的夫妇来说,拥有亲生孩子仍然是一个无法实现的梦想。干细胞与基因编辑技术和器官芯片模型的结合,为先天性发育障碍导致配子发生受损的不育患者或癌症幸存者提供了独特的机会。但这些技术将如何克服人类不孕症呢?本文综述了不同类型干细胞在不孕症患者配子发生中的再生机制、应用和优势,以及临床应用前必须克服的主要挑战。将在人类生殖的背景下讨论从患者特异性人诱导多能干细胞(hiPSCs)体外生成配子的重要性和局限性。该研究还探讨了芯片上器官模型的潜在作用,该模型可以指导hipsc衍生的原始生殖细胞样细胞向配子和其他生殖器官的分化。这些快速发展的技术为生育失败的个人和夫妇提供了提高生育能力的前景。
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Stem Cells and Organs-on-chips: New Promising Technologies for Human Infertility Treatment.

Having biological children remains an unattainable dream for most couples with reproductive failure or gonadal dysgenesis. The combination of stem cells with gene editing technology and organ-on-a-chip models provides a unique opportunity for infertile patients with impaired gametogenesis caused by congenital disorders in sex development or cancer survivors. But how will these technologies overcome human infertility? This review discusses the regenerative mechanisms, applications, and advantages of different types of stem cells for restoring gametogenesis in infertile patients, as well as major challenges that must be overcome before clinical application. The importance and limitations of in vitro generation of gametes from patient-specific human-induced pluripotent stem cells (hiPSCs) will be discussed in the context of human reproduction. The potential role of organ-on-a-chip models that can direct differentiation of hiPSC-derived primordial germ cell-like cells to gametes and other reproductive organoids is also explored. These rapidly evolving technologies provide prospects for improving fertility to individuals and couples who experience reproductive failure.

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来源期刊
Endocrine reviews
Endocrine reviews 医学-内分泌学与代谢
CiteScore
42.00
自引率
1.00%
发文量
29
期刊介绍: Endocrine Reviews, published bimonthly, features concise timely reviews updating key mechanistic and clinical concepts, alongside comprehensive, authoritative articles covering both experimental and clinical endocrinology themes. The journal considers topics informing clinical practice based on emerging and established evidence from clinical research. It also reviews advances in endocrine science stemming from studies in cell biology, immunology, pharmacology, genetics, molecular biology, neuroscience, reproductive medicine, and pediatric endocrinology.
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