7个核心生物钟基因遗传变异与生活方式因素相互作用对代谢参数的影响

IF 2 4区 医学 Q3 GENETICS & HEREDITY Lifestyle Genomics Pub Date : 2022-01-01 DOI:10.1159/000525859
Kimiko Yamakawa-Kobayashi, Sayaka Ishikawa, Nagi Miyake, Yuya Ohhara, Toshinao Goda
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引用次数: 0

摘要

在哺乳动物中,昼夜节律调节着许多行为和生理过程。遗传学和流行病学研究表明,昼夜节律失调可诱发慢性代谢性疾病,如肥胖、糖尿病和血脂异常。我们的目的是了解七个核心生物钟基因的遗传变异与生活方式因素对代谢参数决定的相互作用。方法:我们分析了575名日本男性7个核心生物钟基因(clock、BMAL1、PER1、PER2、PER3、CRY1和CRY2)的基因型和生活方式因素(即体力活动和睡眠时间)对代谢参数(即体重指数[BMI]、血清葡萄糖、糖化血红蛋白[HbA1c]、低密度脂蛋白胆固醇[LDL-C]和高密度脂蛋白胆固醇[HDL-C]水平)测定的影响。结果:我们检测到了PER3基因型与血清HbA1c水平、CRY1基因型与血清LDL-C水平的相关性。此外,我们还观察了PER1和PER3基因型与体力活动测定BMI的相互作用,以及CLOCK基因型与体力活动测定血清HbA1c水平的相互作用。此外,为了确定血清HDL-C水平,观察了CRY2基因型与身体活动或睡眠时间的相互作用。讨论/结论:我们的研究结果表明,核心生物钟基因的基因型与生活方式因素(即体力活动和睡眠时间)的相互作用对于确定代谢参数很重要。
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Influences of the Interactions of Genetic Variations of Seven Core Circadian Clock Genes with Lifestyle Factors on Metabolic Parameters.

Introduction: In mammals, circadian rhythms regulate many behavioral and physiological processes. Genetic and epidemiological studies have shown that dysregulation of the circadian rhythm induces chronic metabolic diseases, such as obesity, diabetes, and dyslipidemia. We aimed to know the interactions of genetic variations of seven core circadian clock genes with lifestyle factors on the determination of metabolic parameters.

Methods: We have analyzed the impacts of genotype of seven core circadian clock genes (i.e., CLOCK, BMAL1, PER1, PER2, PER3, CRY1, and CRY2) and lifestyle factors (i.e., physical activity and sleep duration) in 575 Japanese males on the determination of metabolic parameters (i.e., body mass index [BMI], serum glucose, glycated hemoglobin [HbA1c], low-density lipoprotein cholesterol [LDL-C], and high-density lipoprotein cholesterol [HDL-C] levels).

Results: We have detected the associations between genotypes of PER3 and serum HbA1c level and genotypes of CRY1 and serum LDL-C level. Additionally, the interactions of the genotypes of PER1 and PER3 with physical activity for determining BMI, the genotypes of CLOCK with physical activity for determining serum HbA1c levels were observed. Furthermore, for determining serum HDL-C levels, the interactions of the genotypes of CRY2 with physical activity or sleep duration were observed.

Discussion/conclusion: Our findings indicate that the interactions of genotypes for core circadian clock genes and lifestyle factors (i.e., physical activity and sleep duration) are important for determining metabolic parameters.

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来源期刊
Lifestyle Genomics
Lifestyle Genomics Agricultural and Biological Sciences-Food Science
CiteScore
4.00
自引率
7.70%
发文量
11
审稿时长
28 weeks
期刊介绍: Lifestyle Genomics aims to provide a forum for highlighting new advances in the broad area of lifestyle-gene interactions and their influence on health and disease. The journal welcomes novel contributions that investigate how genetics may influence a person’s response to lifestyle factors, such as diet and nutrition, natural health products, physical activity, and sleep, amongst others. Additionally, contributions examining how lifestyle factors influence the expression/abundance of genes, proteins and metabolites in cell and animal models as well as in humans are also of interest. The journal will publish high-quality original research papers, brief research communications, reviews outlining timely advances in the field, and brief research methods pertaining to lifestyle genomics. It will also include a unique section under the heading “Market Place” presenting articles of companies active in the area of lifestyle genomics. Research articles will undergo rigorous scientific as well as statistical/bioinformatic review to ensure excellence.
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