Allen Jankeel, Izabela Coimbra-Ibraim, Ilhem Messaoudi
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引用次数: 0
摘要
猿猴水痘病毒(SVV)于1966年首次从肯尼亚内罗毕进口到英国利物浦热带医学院的非洲绿猴(Cercopithecus aethiops)中分离出来(Clarkson et al.， Arch Gesamte Virusforsch 22:19 -234, 1967)。SVV感染引起严重疾病，导致进口动物在出现水痘样皮疹48小时内病死率(CFR)达到56% (Clarkson等人，Arch Gesamte Virusforsch 22:219-234, 1967;Hemme et al.， [J] .中华医学杂志，2016(4):1095-1099。死亡动物表现为发热、广泛的水疱疹和遍布肺、肝和脾的多发出血灶(Clarkson等人，Arch Gesamte Virusforsch 22:219- 234,1967)。在这次暴发之后，葛兰素史克实验室(英国伦敦)从乍得和尼日利亚进口了47只猴(猴)，迅速发生了第二次暴发，并在该设施内迅速传播(McCarthy等人，Lancet:856-857, 1968)。
Simian Varicella Virus: Molecular Virology and Mechanisms of Pathogenesis.
Simian varicella virus (SVV) was first isolated in 1966 from African green monkeys (Cercopithecus aethiops) imported from Nairobi, Kenya, to the Liverpool School of Tropical Medicine in the United Kingdom (UK) (Clarkson et al., Arch Gesamte Virusforsch 22:219-234, 1967). SVV infection caused severe disease that resulted in a 56% case fatality rate (CFR) in the imported animals within 48 h of the appearance of a varicella-like rash (Clarkson et al., Arch Gesamte Virusforsch 22:219-234, 1967; Hemme et al., Am J Trop Med Hyg 94:1095-1099, 2016). The deceased animals presented with fever, widespread vesicular rash, and multiple hemorrhagic foci throughout the lungs, liver, and spleen (Clarkson et al., Arch Gesamte Virusforsch 22:219-234, 1967). This outbreak was quickly followed by a second outbreak in 47 patas monkeys (Erythrocebus patas) imported from Chad and Nigeria by Glaxo Laboratories (London, England, UK), which quickly spread within the facility (McCarthy et al., Lancet 2:856-857, 1968).
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