儿童型弥漫性低级别胶质瘤:在临床和生物学上与众不同的一组肿瘤,预后良好。

IF 4.4 Q1 PATHOLOGY PATHOLOGICA Pub Date : 2022-12-01 DOI:10.32074/1591-951X-828
Viscardo Paolo Fabbri, Chiara Caporalini, Sofia Asioli, Annamaria Buccoliero
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引用次数: 0

摘要

世卫组织 2021 年中枢神经系统癌症分类根据临床和分子特征,对成人弥漫性胶质瘤(称为 "成人型")和儿童弥漫性胶质瘤(定义为 "儿童型")进行了区分。)不过,儿童型胶质瘤偶尔也会出现在较年轻的成年人身上,成人型胶质瘤偶尔也会出现在儿童身上。弥漫低级别儿科胶质瘤包括MYB或MYBL1改变的弥漫星形细胞瘤、低级别多形性幼年神经上皮肿瘤、血管中心型胶质瘤和MAPK通路改变的弥漫低级别胶质瘤。在此,我们根据世界卫生组织的诊断标准对这些新发现的实体进行了研究,并提出了一种综合诊断方法,可用于区分这些在临床和生物学上截然不同的肿瘤组别。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Paediatric-type diffuse low-grade gliomas: a clinically and biologically distinct group of tumours with a favourable outcome.

The WHO 2021 classification of central nervous system cancers distinguishes diffuse gliomas that arise in adults (referred to as the "adult type") and those that arise in children (defined as "paediatric") based on clinical and molecular characteristics."). However, paediatric-type gliomas may occasionally be present in younger adults and occasionally adult-type gliomas may occur in children. Diffuse low-grade paediatric glioma includes diffuse astrocytoma altered by MYB or MYBL1, low-grade polymorphic juvenile neuroepithelial tumour, angiocentric glioma, and diffuse low-grade glioma with an altered MAPK pathway. Here, we examine these newly recognised entities according to WHO diagnostic criteria and propose an integrated diagnostic approach that can be used to separate these clinically and biologically distinct tumor groups.

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来源期刊
PATHOLOGICA
PATHOLOGICA PATHOLOGY-
CiteScore
5.90
自引率
5.70%
发文量
108
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