尿1h NMR代谢组学鉴别前列腺癌患者与非前列腺癌患者。

IF 1.9 3区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Magnetic Resonance in Chemistry Pub Date : 2023-09-01 DOI:10.1002/mrc.5391
Anna-Laura Hasubek, Xiaoyu Wang, Ella Zhang, Marta Kobus, Jiashang Chen, Lindsey A. Vandergrift, Annika Kurreck, Felix Ehret, Sarah Dinges, Annika Hohm, Marlon Tilgner, Alexander Buko, Piet Habbel, Johannes Nowak, Nathaniel D. Mercaldo, Andrew Gusev, Adam S. Feldman, Leo L. Cheng
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引用次数: 0

摘要

前列腺癌(PCa)是世界范围内最常见的男性癌症之一。血清前列腺特异性抗原(PSA)筛查是常用的检测方法,但它缺乏特异性,假阳性率高,无法区分惰性和侵袭性前列腺癌。随着血清PSA水平的升高,临床医生通常在有或没有先进成像的情况下进行前列腺活检。基于核磁共振(NMR)的代谢组学已被证明有希望通过发现和表征新的生物标志物来推进疾病进展的早期检测和阐明。这项回顾性研究对有和没有前列腺癌的前列腺活检患者的尿液核磁共振样本进行了研究,发现了一些参与能量代谢、氨基酸代谢和马尿酸途径的代谢物。值得注意的是,乳酸和马粪酸——分别参与细胞增殖和微生物组效应的关键代谢物——被显著改变,揭示了与PCa发展相关的广泛代谢组学修饰。这些发现支持尿液代谢组学分析作为鉴别前列腺癌检测和诊断的新临床生物标志物的一种有前景的策略。
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Differentiation of patients with and without prostate cancer using urine 1H NMR metabolomics

Prostate cancer (PCa) is one of the most prevalent cancers in men worldwide. For its detection, serum prostate-specific antigen (PSA) screening is commonly used, despite its lack of specificity, high false positive rate, and inability to discriminate indolent from aggressive PCa. Following increases in serum PSA levels, clinicians often conduct prostate biopsies with or without advanced imaging. Nuclear magnetic resonance (NMR)-based metabolomics has proven to be promising for advancing early-detection and elucidation of disease progression, through the discovery and characterization of novel biomarkers. This retrospective study of urine-NMR samples, from prostate biopsy patients with and without PCa, identified several metabolites involved in energy metabolism, amino acid metabolism, and the hippuric acid pathway. Of note, lactate and hippurate—key metabolites involved in cellular proliferation and microbiome effects, respectively—were significantly altered, unveiling widespread metabolomic modifications associated with PCa development. These findings support urine metabolomics profiling as a promising strategy to identify new clinical biomarkers for PCa detection and diagnosis.

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来源期刊
CiteScore
4.70
自引率
10.00%
发文量
99
审稿时长
1 months
期刊介绍: MRC is devoted to the rapid publication of papers which are concerned with the development of magnetic resonance techniques, or in which the application of such techniques plays a pivotal part. Contributions from scientists working in all areas of NMR, ESR and NQR are invited, and papers describing applications in all branches of chemistry, structural biology and materials chemistry are published. The journal is of particular interest not only to scientists working in academic research, but also those working in commercial organisations who need to keep up-to-date with the latest practical applications of magnetic resonance techniques.
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