口腔微生物群在癌症中的作用:多酚的应用能让坏家伙变好吗?

IF 4.5 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Expert Reviews in Molecular Medicine Pub Date : 2022-12-13 DOI:10.1017/erm.2022.39
Mariya Gover Antoniraj, Kasi Pandima Devi, Ioana Berindan-Neagoe, Seyed Fazel Nabavi, Hamid Reza Khayat Kashani, Safieh Aghaabdollahian, Farzaneh Afkhami, Philippe Jeandet, Zahra Lorigooini, Maryam Khayatkashani, Seyed Mohammad Nabavi
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引用次数: 0

摘要

人类口腔是由动态和多项式微生物组成的,它们独特地生活在口腔微环境中。共生微生物群落的累积功能维持正常的体内平衡;然而,转移的微生物群会产生生态失调状态,从而产生局部和全身性疾病,包括龋齿、牙周炎、癌症、肥胖和糖尿病。最近的研究报告称,口腔生态失调与包括口腔癌、胃癌和胰腺癌在内的不同类型癌症的进展之间存在关联。对于癌症的发展提出了不同的机制,例如诱导炎症反应,致癌物质的产生和免疫系统的改变。有治疗这些相关疾病的药物;然而,目前的策略可能会因不必要的副作用而进一步恶化疾病。天然衍生的多酚分子显著抑制广泛的系统性疾病,副作用少。在这篇综述中,我们展示了口腔微生物的功能,并扩展了多酚在口腔微生物群中的作用,以维持健康状况和预防疾病,重点是口腔微生物群相关癌症的治疗。
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Oral microbiota in cancer: could the bad guy turn good with application of polyphenols?

The human oral cavity is comprised of dynamic and polynomial microbes which uniquely reside in the microenvironments of oral cavities. The cumulative functions of the symbiotic microbial communities maintain normal homeostasis; however, a shifted microbiota yields a dysbiosis state, which produces local and systemic diseases including dental caries, periodontitis, cancer, obesity and diabetes. Recent research reports claim that an association occurs between oral dysbiosis and the progression of different types of cancers including oral, gastric and pancreatic ones. Different mechanisms are proposed for the development of cancer, such as induction of inflammatory reactions, production of carcinogenic materials and alteration of the immune system. Medications are available to treat these associated diseases; however, the current strategies may further worsen the disease by unwanted side effects. Natural-derived polyphenol molecules significantly inhibit a wide range of systemic diseases with fewer side effects. In this review, we have displayed the functions of the oral microbes and we have extended the report regarding the role of polyphenols in oral microbiota to maintain healthy conditions and prevention of diseases with emphasis on the treatment of oral microbiota-associated cancer.

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来源期刊
Expert Reviews in Molecular Medicine
Expert Reviews in Molecular Medicine BIOCHEMISTRY & MOLECULAR BIOLOGY-MEDICINE, RESEARCH & EXPERIMENTAL
CiteScore
7.40
自引率
1.60%
发文量
45
期刊介绍: Expert Reviews in Molecular Medicine is an innovative online journal featuring authoritative and timely Reviews covering gene therapy, immunotherapeutics, drug design, vaccines, genetic testing, pathogenesis, microbiology, genomics, molecular epidemiology and diagnostic techniques. We especially welcome reviews on translational aspects of molecular medicine, particularly those related to the application of new understanding of the molecular basis of disease to experimental medicine and clinical practice.
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