{"title":"68Ga-FAPI PET CT对肾盂肾炎的定位。","authors":"Rajlaxmi Rangrao Jagtap, Shailendra Vasant Savale, Gauri Shridhar Khajindar, Shrikant Vasantrao Solav","doi":"10.22038/AOJNMB.2022.64168.1450","DOIUrl":null,"url":null,"abstract":"<p><p>Fibroblast activation protein inhibitor (FAPI) is a quinoline-based membrane-bound glycoprotein enzyme that is not usually expressed in normal adult tissues, except for the myometrium and sometimes the pancreas. Its expression increases in inflammation and cancer-associated fibroblasts (CAF). As FAPI is a new molecule with a promising future, presented here is a case report of uncontrolled diabetes with abdominal pain that showed features of inflammation in the kidneys. The patient had been previously diagnosed with maxillary sinusitis with Aspergillus niger and was receiving antibiotic treatment. The urine culture performed later was negative, and the patient was referred for <sup>18</sup>F-fluorodeoxyglucose (<sup>18</sup>F-FDG) PET Computed Tomography (CT) to look for the focus of infection. However, as blood sugar was 500 mg/dL, <sup>18</sup>F-FDG PET CT could not be performed. Therefore, <sup>68</sup>Ga-FAPI PET CT was run instead after taking the patient's written informed consent. The <sup>99m</sup>Tc-dimercaptosuccinic acid scan performed on another day confirmed the presence of pyelonephritis bilaterally. In situations where FDG cannot be used because of hyperglycemia, <sup>68</sup>Ga-FAPI PET CT scan may be considered an alternative in the detection of occult infection or inflammation, as demonstrated in this case report.</p>","PeriodicalId":8503,"journal":{"name":"Asia Oceania Journal of Nuclear Medicine and Biology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9803616/pdf/","citationCount":"3","resultStr":"{\"title\":\"Localization of Pyelonephritis by <sup>68</sup>Ga-FAPI PET CT.\",\"authors\":\"Rajlaxmi Rangrao Jagtap, Shailendra Vasant Savale, Gauri Shridhar Khajindar, Shrikant Vasantrao Solav\",\"doi\":\"10.22038/AOJNMB.2022.64168.1450\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Fibroblast activation protein inhibitor (FAPI) is a quinoline-based membrane-bound glycoprotein enzyme that is not usually expressed in normal adult tissues, except for the myometrium and sometimes the pancreas. Its expression increases in inflammation and cancer-associated fibroblasts (CAF). As FAPI is a new molecule with a promising future, presented here is a case report of uncontrolled diabetes with abdominal pain that showed features of inflammation in the kidneys. The patient had been previously diagnosed with maxillary sinusitis with Aspergillus niger and was receiving antibiotic treatment. The urine culture performed later was negative, and the patient was referred for <sup>18</sup>F-fluorodeoxyglucose (<sup>18</sup>F-FDG) PET Computed Tomography (CT) to look for the focus of infection. However, as blood sugar was 500 mg/dL, <sup>18</sup>F-FDG PET CT could not be performed. Therefore, <sup>68</sup>Ga-FAPI PET CT was run instead after taking the patient's written informed consent. The <sup>99m</sup>Tc-dimercaptosuccinic acid scan performed on another day confirmed the presence of pyelonephritis bilaterally. In situations where FDG cannot be used because of hyperglycemia, <sup>68</sup>Ga-FAPI PET CT scan may be considered an alternative in the detection of occult infection or inflammation, as demonstrated in this case report.</p>\",\"PeriodicalId\":8503,\"journal\":{\"name\":\"Asia Oceania Journal of Nuclear Medicine and Biology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9803616/pdf/\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Asia Oceania Journal of Nuclear Medicine and Biology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.22038/AOJNMB.2022.64168.1450\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Asia Oceania Journal of Nuclear Medicine and Biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.22038/AOJNMB.2022.64168.1450","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 3
摘要
成纤维细胞活化蛋白抑制剂(FAPI)是一种基于喹啉的膜结合糖蛋白酶,除肌层和胰腺外,在正常成人组织中通常不表达。它在炎症和癌症相关成纤维细胞(CAF)中的表达增加。由于FAPI是一种很有前景的新分子,这里报告了一例未控制的糖尿病合并腹痛,表现为肾脏炎症特征。患者曾被诊断为上颌鼻窦炎伴黑曲霉,并正在接受抗生素治疗。随后进行的尿培养为阴性,患者被转诊进行18f -氟脱氧葡萄糖(18F-FDG) PET计算机断层扫描(CT)以寻找感染病灶。但由于血糖为500mg /dL,无法进行18F-FDG PET CT检查。因此,在征得患者书面知情同意后,改为运行68Ga-FAPI PET CT。另一天进行的99mtc -二巯基琥珀酸扫描证实了双侧肾盂肾炎的存在。在由于高血糖而不能使用FDG的情况下,68Ga-FAPI PET CT扫描可以被认为是检测隐匿性感染或炎症的替代方法,如本病例报告所示。
Localization of Pyelonephritis by 68Ga-FAPI PET CT.
Fibroblast activation protein inhibitor (FAPI) is a quinoline-based membrane-bound glycoprotein enzyme that is not usually expressed in normal adult tissues, except for the myometrium and sometimes the pancreas. Its expression increases in inflammation and cancer-associated fibroblasts (CAF). As FAPI is a new molecule with a promising future, presented here is a case report of uncontrolled diabetes with abdominal pain that showed features of inflammation in the kidneys. The patient had been previously diagnosed with maxillary sinusitis with Aspergillus niger and was receiving antibiotic treatment. The urine culture performed later was negative, and the patient was referred for 18F-fluorodeoxyglucose (18F-FDG) PET Computed Tomography (CT) to look for the focus of infection. However, as blood sugar was 500 mg/dL, 18F-FDG PET CT could not be performed. Therefore, 68Ga-FAPI PET CT was run instead after taking the patient's written informed consent. The 99mTc-dimercaptosuccinic acid scan performed on another day confirmed the presence of pyelonephritis bilaterally. In situations where FDG cannot be used because of hyperglycemia, 68Ga-FAPI PET CT scan may be considered an alternative in the detection of occult infection or inflammation, as demonstrated in this case report.