人类内源性逆转录病毒:泌尿外科诊所的朋友和敌人。

IF 1.8 3区医学 Q3 UROLOGY & NEPHROLOGY International Neurourology Journal Pub Date : 2022-12-01 DOI:10.5213/inj.2244284.142

Sun-Kyung Lee, Seung Hyun Kim, Joohong Ahnn

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摘要

人类内源性逆转录病毒(herv)起源于数百万年前感染人类生殖系细胞的古老外源性逆转录病毒。herv通常失去了复制和反转录的能力，但在人类生物学中发挥了生理作用。虽然大多数herv不活跃，但它可以被炎症和环境条件等内部和外部因素重新激活。它们的异常表达可参与多种病因复杂的人类恶性肿瘤。本文综述了herv在泌尿系统疾病中的特征和功能，如泌尿系统癌症和人类生殖。它提供了当前的herv知识和有用的见解，有助于泌尿外科诊所的实践。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Human Endogenous Retroviruses: Friends and Foes in Urology Clinics.

Human endogenous retroviruses (HERVs) are originated from ancient exogenous retroviruses, which infected human germ line cells millions of years ago. HERVs have generally lost their replication and retrotransposition abilities, but adopted physiological roles in human biology. Though mostly inactive, HERVs can be reactivated by internal and external factors such as inflammations and environmental conditions. Their aberrant expression can participate in various human malignancies with complex etiology. This review describes the features and functions of HERVs in urological subjects, such as urological cancers and human reproduction. It provides the current knowledge of the HERVs and useful insights helping practice in urology clinics.

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来源期刊

International Neurourology Journal UROLOGY & NEPHROLOGY-

CiteScore

4.40

自引率

21.70%

发文量

审稿时长

4 weeks

期刊介绍： The International Neurourology Journal (Int Neurourol J, INJ) is a quarterly international journal that publishes high-quality research papers that provide the most significant and promising achievements in the fields of clinical neurourology and fundamental science. Specifically, fundamental science includes the most influential research papers from all fields of science and technology, revolutionizing what physicians and researchers practicing the art of neurourology worldwide know. Thus, we welcome valuable basic research articles to introduce cutting-edge translational research of fundamental sciences to clinical neurourology. In the editorials, urologists will present their perspectives on these articles. The original mission statement of the INJ was published on October 12, 1997. INJ provides authors a fast review of their work and makes a decision in an average of three to four weeks of receiving submissions. If accepted, articles are posted online in fully citable form. Supplementary issues will be published interim to quarterlies, as necessary, to fully allow berth to accept and publish relevant articles.