通过运动调节骨骼肌中的 eEF2 和 eEF2K。

IF 2.5 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM Archives of Physiology and Biochemistry Pub Date : 2024-10-01 Epub Date: 2023-01-12 DOI:10.1080/13813455.2023.2164898
Kia Salimi, Masoomeh Alvandi, Mahdi Saberi Pirouz, Kamran Rakhshan, Glyn Howatson
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引用次数: 0

摘要

骨骼肌是一种灵活、适应性强的组织,对运动训练有强烈的反应。当能量充足时,骨骼肌会通过增加肌肉蛋白质合成(MPS)对运动做出反应。蛋白质合成的主要限速和关键调节步骤之一是翻译伸长途径。骨骼肌中的翻译延伸过程受到高度调控。它需要受到各种生理刺激(如运动和细胞可利用的总能量)强烈影响的伸长因子。研究表明,运动通过多种信号通路参与了伸长途径。由于对伸长途径的研究远远少于对其他翻译步骤的研究,因此对其全面前景和定量了解仍处于黑暗之中。本研究着重介绍了目前对运动训练对翻译伸长通路影响的认识,重点是影响该通路的分子因素,包括 Ca2+、AMPK、PKA、mTORC1/P70S6K、MAPKs 和 myostatin。我们还进一步讨论了运动训练对翻译延长通路的干预模式和干预量。本综述总结了运动训练对骨骼肌翻译延长通路的影响,重点关注 eEF2 和 eEF2K。本综述强调了深刻影响翻译延长途径的机制和因素,并认为运动可能会调节这种反应。这篇综述还结合了实验观察,重点关注运动过程中和运动后翻译延伸的调控。这些发现拓宽了我们的视野,使我们认识到通过翻译伸长对运动训练的反应参与肌肉蛋白质合成(MPS)的机制。
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Regulating eEF2 and eEF2K in skeletal muscle by exercise.

Skeletal muscle is a flexible and adaptable tissue that strongly responds to exercise training. The skeletal muscle responds to exercise by increasing muscle protein synthesis (MPS) when energy is available. One of protein synthesis's major rate-limiting and critical regulatory steps is the translation elongation pathway. The process of translation elongation in skeletal muscle is highly regulated. It requires elongation factors that are intensely affected by various physiological stimuli such as exercise and the total available energy of cells. Studies have shown that exercise involves the elongation pathway by numerous signalling pathways. Since the elongation pathway, has been far less studied than the other translation steps, its comprehensive prospect and quantitative understanding remain in the dark. This study highlights the current understanding of the effect of exercise training on the translation elongation pathway focussing on the molecular factors affecting the pathway, including Ca2+, AMPK, PKA, mTORC1/P70S6K, MAPKs, and myostatin. We further discussed the mode and volume of exercise training intervention on the translation elongation pathway.What is the topic of this review? This review summarises the impacts of exercise training on the translation elongation pathway in skeletal muscle focussing on eEF2 and eEF2K.What advances does it highlight? This review highlights mechanisms and factors that profoundly influence the translation elongation pathway and argues that exercise might modulate the response. This review also combines the experimental observations focussing on the regulation of translation elongation during and after exercise. The findings widen our horizon to the notion of mechanisms involved in muscle protein synthesis (MPS) through translation elongation response to exercise training.

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来源期刊
Archives of Physiology and Biochemistry
Archives of Physiology and Biochemistry ENDOCRINOLOGY & METABOLISM-PHYSIOLOGY
CiteScore
6.90
自引率
3.30%
发文量
21
期刊介绍: Archives of Physiology and Biochemistry: The Journal of Metabolic Diseases is an international peer-reviewed journal which has been relaunched to meet the increasing demand for integrated publication on molecular, biochemical and cellular aspects of metabolic diseases, as well as clinical and therapeutic strategies for their treatment. It publishes full-length original articles, rapid papers, reviews and mini-reviews on selected topics. It is the overall goal of the journal to disseminate novel approaches to an improved understanding of major metabolic disorders. The scope encompasses all topics related to the molecular and cellular pathophysiology of metabolic diseases like obesity, type 2 diabetes and the metabolic syndrome, and their associated complications. Clinical studies are considered as an integral part of the Journal and should be related to one of the following topics: -Dysregulation of hormone receptors and signal transduction -Contribution of gene variants and gene regulatory processes -Impairment of intermediary metabolism at the cellular level -Secretion and metabolism of peptides and other factors that mediate cellular crosstalk -Therapeutic strategies for managing metabolic diseases Special issues dedicated to topics in the field will be published regularly.
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