衰老是 "正常 "的吗?

Aging pathobiology and therapeutics Pub Date : 2022-01-01 Epub Date: 2022-12-29
Chloe Johnson, Warren Ladiges
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引用次数: 0

摘要

在科学文献中,"正常 "衰老这一描述性术语经常被用来表示在没有明显疾病的情况下,随着年龄的增长而普遍发生的变化。然而,越来越多的分子和老年病理变化表明,衰老并不正常。因此,"正常 "衰老一词在科学上是不正确的。多种遗传和表观遗传过程和途径的变化是衰老的驱动力,有些人比其他人更能适应这些变化。因此,"复原力 "衰老是一个更正确的术语,它代表了研究复原力机制和治疗目标的主要重点,而不是一个 "正常 "衰老的标签,它具有误导性,目前受到的关注相对较少。
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Is aging "normal"?

The descriptive term "normal" aging is often used in scientific literature to indicate commonly occurring changes with increasing age in the absence of overt disease. However, significant molecular and geropathological changes are increasingly present to indicate there is nothing normal about aging. Thus, the term "normal" aging is scientifically incorrect. There are changes in multiple genetic and epigenetic processes and pathways that drive aging, and some individuals are more resilient to these changes than others. Thus, "resilient" aging would be a more correct term to represent a major emphasis on investigating mechanisms and therapeutic targets for resilience, rather than a label of "normal" aging that is misleading and currently receives relatively little attention.

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