派姆单抗诱导骨化三醇介导的高钙血症。

Tiffany T Oommen, Kelly Sun, Javier Barranco-Trabi, Jeffrey Berenberg, Myungjin Kim
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引用次数: 1

摘要

PD-1/PD-L1抑制剂如派姆单抗已经从根本上改善了许多晚期恶性肿瘤患者的预后。虽然是革命性的,但它的使用可能会很复杂,并受到各种与免疫有关的不良反应的限制。有效的管理取决于早期发现和及时干预。在此,我们描述了一种独特的高钙血症综合征,伴有急性肾损伤和缺氧呼吸衰竭,对皮质类固醇有反应,提示派姆单抗的免疫毒性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Pembrolizumab Induced Calcitriol-Mediated Hypercalcemia.

PD-1/PD-L1 inhibitors such as pembrolizumab have radically improved the prognosis for many patients with advanced malignancies. Although revolutionary, its use can be complicated and limited by various immune-related adverse effects. Effective management depends on early recognition and prompt intervention. Herein, we describe a unique syndrome of hypercalcemia, with associated acute renal injury and hypoxic respiratory failure that was responsive to corticosteroids suggestive of immunotoxicity from pembrolizumab.

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来源期刊
Case Reports in Nephrology
Case Reports in Nephrology Medicine-Nephrology
CiteScore
1.70
自引率
0.00%
发文量
32
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