冷漠在自发语言和非语言行为中的作用:一项神经变性的跨诊断初步研究。

IF 1.3 4区 医学 Q4 BEHAVIORAL SCIENCES Cognitive and Behavioral Neurology Pub Date : 2023-09-01 DOI:10.1097/WNN.0000000000000345
Kristina S Horne, Amelia Ceslis, Philip Mosley, Robert Adam, Gail A Robinson
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引用次数: 0

摘要

背景:冷漠,以动机或目标导向行为的可量化减少为特征,是在许多神经退行性疾病中观察到的多维综合征。目的:开发一种测量自发行动启动的新任务(即,相当于自发言语任务的非语言任务),并研究冷漠与执行功能(如自愿启动言语和行动以及激活(即发起和维持反应的能力)之间的关系。方法:我们比较了10例神经退行性疾病和临床显著冷漠患者的能量和执行功能表现与年龄匹配的健康对照(HC)。我们还调查了冷漠评估量表(AES)自我报告得分与激励任务表现之间的关系。结果:冷漠个体在新自发行动任务上的任务相关行为显著少于高情商个体,其AES得分与自发任务相关行为呈负相关,为任务的构效度提供了初步证据。此外,无论任务类型或刺激方式如何,冷漠个体在所有激活任务上的表现都比HC表现更差,这表明他们难以长期维持自愿反应。大多数任务也与AES得分呈负相关。然而,冷漠的人在一些执行功能任务上的表现也更差,尤其是那些涉及自我监控的任务。结论:我们的工作提出了一个新的实验任务来测量自发行动启动——冷漠的一个关键症状——并提出了冷漠可能对神经心理缺陷(如能量不足)的贡献。
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The Role of Apathy in Spontaneous Verbal and Nonverbal Behaviors: A Transdiagnostic Pilot Study in Neurodegeneration.

Background: Apathy, characterized by a quantifiable reduction in motivation or goal-directed behavior, is a multidimensional syndrome that has been observed across many neurodegenerative diseases.

Objective: To develop a novel task measuring spontaneous action initiation (ie, a nonverbal equivalent to spontaneous speech tasks) and to investigate the association between apathy and executive functions such as the voluntary initiation of speech and actions and energization (ie, ability to initiate and sustain a response).

Method: We compared the energization and executive functioning performance of 10 individuals with neurodegenerative disease and clinically significant apathy with that of age-matched healthy controls (HC). We also investigated the association between self-reported scores on the Apathy Evaluation Scale (AES) and performance on energization tasks.

Results: The individuals with apathy made significantly fewer task-related actions than the HC on the novel spontaneous action task, and their scores on the AES were negatively correlated with spontaneous task-related actions, providing preliminary evidence for the task's construct validity. In addition, the individuals with apathy performed more poorly than the HC on all of the energization tasks, regardless of task type or stimulus modality, suggesting difficulty in sustaining voluntary responding over time. Most of the tasks also correlated negatively with the AES score. However, the individuals with apathy also performed more poorly on some of the executive function tasks, particularly those involving self-monitoring.

Conclusion: Our work presents a novel experimental task for measuring spontaneous action initiation-a key symptom of apathy-and suggests a possible contribution of apathy to neuropsychological deficits such as poor energization.

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来源期刊
CiteScore
2.40
自引率
7.10%
发文量
68
审稿时长
>12 weeks
期刊介绍: Cognitive and Behavioral Neurology (CBN) is a forum for advances in the neurologic understanding and possible treatment of human disorders that affect thinking, learning, memory, communication, and behavior. As an incubator for innovations in these fields, CBN helps transform theory into practice. The journal serves clinical research, patient care, education, and professional advancement. The journal welcomes contributions from neurology, cognitive neuroscience, neuropsychology, neuropsychiatry, and other relevant fields. The editors particularly encourage review articles (including reviews of clinical practice), experimental and observational case reports, instructional articles for interested students and professionals in other fields, and innovative articles that do not fit neatly into any category. Also welcome are therapeutic trials and other experimental and observational studies, brief reports, first-person accounts of neurologic experiences, position papers, hypotheses, opinion papers, commentaries, historical perspectives, and book reviews.
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