Katie M Hamel, Kara Q Liimatta, Jorge A Belgodere, Bruce A Bunnell, Jeffrey M Gimble, Elizabeth C Martin
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Adipose-Derived Stromal/Stem Cell Response to Tumors and Wounds: Evaluation of Patient Age.
Tumors were characterized as nonhealing wounds by Virchow in 1858 and Dvorak in 1986. Since then, researchers have analyzed tumors from a new perspective. The parallels between tumorigenesis and physiological wound healing can provide a new framework for developing antitumor therapeutics. One commonality between tumors and wounds is the involvement of the stromal environment, particularly adipose stromal/stem cells (ASCs). ASCs exhibit dual functions, in which they stimulate tumor progression and assist in tissue repair and regeneration. Numerous studies have focused on the role of ASCs in cancer and wound healing, but none to date has linked age, cancer, and wound healing. Furthermore, very few studies have focused on the role of donor-specific characteristics of ASCs, such as age and their role in facilitating ASC behavior in cancer and wound healing. This review article is designed to provide important insights into the impact of donor age on ASC tumor and wound response and their role in facilitating ASC behavior in cancer and wound healing.
期刊介绍：
Stem Cells and Development is globally recognized as the trusted source for critical, even controversial coverage of emerging hypotheses and novel findings. With a focus on stem cells of all tissue types and their potential therapeutic applications, the Journal provides clinical, basic, and translational scientists with cutting-edge research and findings.
Stem Cells and Development coverage includes:
Embryogenesis and adult counterparts of this process
Physical processes linking stem cells, primary cell function, and structural development
Hypotheses exploring the relationship between genotype and phenotype
Development of vasculature, CNS, and other germ layer development and defects
Pluripotentiality of embryonic and somatic stem cells
The role of genetic and epigenetic factors in development
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