Maoyuan Zhao , Yi Yang , Qing Nian , Caifei Shen , Xiaolin Xiao , Wenhao Liao , Qiao Zheng , Gang Zhang , Nianzhi Chen , Daoyin Gong , Jianyuan Tang , Yueqiang Wen , Jinhao Zeng
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Studies have shown that some phytochemicals can suppress the development of gastric cancer.</p></div><div><h3>Methods</h3><p>We searched for data from PubMed, China National Knowledge Infrastructure, Web of Science, and Embase databases from initial establishment to December 2021 to review the mechanism by which phytochemicals suppress gastric cancer cell growth by modulating mitochondrial function. Phytochemicals were classified and summarized by their mechanisms of action.</p></div><div><h3>Results</h3><p><span>Phytochemicals can interfere with mitochondria through several mechanisms to reach the goal of promoting apoptosis in gastric cancer cells. Some phytochemicals, </span><em>e.g.</em><span>, daidzein<span> and tetrandrine<span> promoted cytochrome c<span> spillover into the cytoplasm by modulating the members of the B-cell lymphoma-2 protein family and induced apoptotic body activity by activating the caspase protein family. Phytochemicals (</span></span></span></span><em>e.g.</em><span><span>, celastrol and shikonin) could promote the accumulation of </span>reactive oxygen species<span> and reduce the mitochondrial membrane potential. Several phytochemicals (</span></span><em>e.g.</em><span><span>, berberine and oleanolic acid) activated mitochondrial apoptotic submission via the phosphatidylinositol-3-kinase/Akt signaling pathway, thereby triggering apoptosis in gastric cancer cells. Several well-known phytochemicals that target mitochondria, including berberine, </span>ginsenoside<span>, and baicalein, showed the advantages of multiple targets, high efficacy, and fewer side effects.</span></span></p></div><div><h3>Conclusions</h3><p>Phytochemicals could target the mitochondria in the treatment of gastric cancer, providing potential directions and evidence for clinical translation. 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Existing drugs targeting mitochondria in cancer </span>treatment have disadvantages of drug resistance and side effects. </span></span>Phytochemicals, which are widely found in plants, are bioactive compounds that could facilitate the development of new drugs for gastric cancer. Studies have shown that some phytochemicals can suppress the development of gastric cancer.</p></div><div><h3>Methods</h3><p>We searched for data from PubMed, China National Knowledge Infrastructure, Web of Science, and Embase databases from initial establishment to December 2021 to review the mechanism by which phytochemicals suppress gastric cancer cell growth by modulating mitochondrial function. Phytochemicals were classified and summarized by their mechanisms of action.</p></div><div><h3>Results</h3><p><span>Phytochemicals can interfere with mitochondria through several mechanisms to reach the goal of promoting apoptosis in gastric cancer cells. 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引用次数: 2
摘要
线粒体是细胞的能量工厂，具有调节细胞周期、细胞分化、信号转导、生长和凋亡的能力。现有靶向线粒体治疗癌症的药物存在耐药和副作用等缺点。植物化学物质广泛存在于植物中，是一类具有生物活性的化合物，可以促进胃癌新药的开发。研究表明，一些植物化学物质可以抑制胃癌的发展。方法检索PubMed、中国国家知识基础设施、Web of Science和Embase数据库自建立之初至2021年12月的数据，回顾植物化学物质通过调节线粒体功能抑制胃癌细胞生长的机制。对植物化学物质的作用机制进行了分类和综述。结果植物化学物质可通过多种机制干扰线粒体，从而达到促进胃癌细胞凋亡的目的。一些植物化学物质如大豆苷元和粉防己碱通过调节b细胞淋巴瘤-2蛋白家族成员促进细胞色素c外溢到细胞质中，并通过激活caspase蛋白家族诱导凋亡小体活性。植物化学物质(如雷公藤红素和紫草素)可以促进活性氧的积累，降低线粒体膜电位。几种植物化学物质(如小檗碱和齐墩果酸)通过磷脂酰肌醇-3-激酶/Akt信号通路激活线粒体凋亡，从而引发胃癌细胞凋亡。一些众所周知的靶向线粒体的植物化学物质，包括小檗碱、人参皂苷和黄芩素，显示出多靶点、高效、副作用少的优点。结论植物化学物质可靶向线粒体治疗胃癌，为临床转化提供了潜在的方向和依据。以植物化学物质为核心的药物开发具有突破癌症治疗障碍的巨大潜力。
Phytochemicals and mitochondria: Therapeutic allies against gastric cancer
Background
Mitochondria are the energy factories of cells with the ability to modulate the cell cycle, cellular differentiation, signal transduction, growth, and apoptosis. Existing drugs targeting mitochondria in cancer treatment have disadvantages of drug resistance and side effects. Phytochemicals, which are widely found in plants, are bioactive compounds that could facilitate the development of new drugs for gastric cancer. Studies have shown that some phytochemicals can suppress the development of gastric cancer.
Methods
We searched for data from PubMed, China National Knowledge Infrastructure, Web of Science, and Embase databases from initial establishment to December 2021 to review the mechanism by which phytochemicals suppress gastric cancer cell growth by modulating mitochondrial function. Phytochemicals were classified and summarized by their mechanisms of action.
Results
Phytochemicals can interfere with mitochondria through several mechanisms to reach the goal of promoting apoptosis in gastric cancer cells. Some phytochemicals, e.g., daidzein and tetrandrine promoted cytochrome c spillover into the cytoplasm by modulating the members of the B-cell lymphoma-2 protein family and induced apoptotic body activity by activating the caspase protein family. Phytochemicals (e.g., celastrol and shikonin) could promote the accumulation of reactive oxygen species and reduce the mitochondrial membrane potential. Several phytochemicals (e.g., berberine and oleanolic acid) activated mitochondrial apoptotic submission via the phosphatidylinositol-3-kinase/Akt signaling pathway, thereby triggering apoptosis in gastric cancer cells. Several well-known phytochemicals that target mitochondria, including berberine, ginsenoside, and baicalein, showed the advantages of multiple targets, high efficacy, and fewer side effects.
Conclusions
Phytochemicals could target the mitochondria in the treatment of gastric cancer, providing potential directions and evidence for clinical translation. Drug discovery focused on phytochemicals has great potential to break barriers in cancer treatment.
期刊介绍：
Phytomedicine is a therapy-oriented journal that publishes innovative studies on the efficacy, safety, quality, and mechanisms of action of specified plant extracts, phytopharmaceuticals, and their isolated constituents. This includes clinical, pharmacological, pharmacokinetic, and toxicological studies of herbal medicinal products, preparations, and purified compounds with defined and consistent quality, ensuring reproducible pharmacological activity. Founded in 1994, Phytomedicine aims to focus and stimulate research in this field and establish internationally accepted scientific standards for pharmacological studies, proof of clinical efficacy, and safety of phytomedicines.
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