尼日利亚一家医院原发性开角型青光眼患者药物治疗与手术治疗的生活质量。

IF 0.5 Q4 OPHTHALMOLOGY Middle East African Journal of Ophthalmology Pub Date : 2022-11-23 eCollection Date: 2022-01-01 DOI:10.4103/meajo.meajo_146_22

Femi C Oduneye, Kareem O Musa, Sefinat A Agboola, Oluwatobi O Idowu, Adeola O Onakoya

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引用次数: 0

摘要

目的：本研究旨在比较尼日利亚拉各斯拉各斯大学教学医院原发性开角型青光眼（POAG）患者药物治疗与手术治疗的生活质量（QoL）：该研究是一项基于医院的横断面比较研究。连续招募符合纳入标准且同意接受治疗的 POAG 患者，直至达到样本量。使用青光眼 QoL-15 和美国国家眼科研究所视觉功能问卷-25（NEI-VFQ-25）对所有参与者的 QoL 进行评估。分析采用 IBM 社会科学统计软件包 25.0 版：该研究涉及 81 名仅接受药物治疗的 POAG 患者和 81 名接受小梁切除手术的年龄和性别相匹配的 POAG 患者。手术治疗者的平均眼压为 11.68 mmHg，低于药物治疗者的 14.82 mmHg。然而，通过青光眼 QoL-15 问卷（药物治疗为 34.36 ± 10.4，手术治疗为 39.11 ± 13.9，P = 0.015）和 NEI-VFQ-25 问卷（药物治疗为 68.32 ± 15.0，手术治疗为 62.44 ± 18.8，P = 0.029），药物治疗参与者的总体平均青光眼 QoL 值更高。使用青光眼 QoL-15 问卷对青光眼的严重程度进行控制后发现，只有在严重 POAG 患者中，接受药物治疗的患者的 QoL 更好（药物治疗为 49.13 ± 5.9，手术治疗为 54.06 ± 4.6，P = 0.003）。在使用NEI-VFQ-25问卷时，只有中度（内科74.70±6.6，外科67.07±15.6 P = 0.012）和重度POAG患者（内科54.52±6.3，外科45.51±10.0 P = 0.004）接受内科治疗的患者的QoL显著更高：研究表明，虽然小梁切除术参与者的平均眼压较低，但与接受药物治疗的参与者相比，他们的总体平均生活质量有所下降。

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The Quality of Life of Medically Versus Surgically Treated Primary Open-angle Glaucoma Patients at a Nigerian Hospital.

Purpose: The purpose of this study is to compare the quality of life (QoL) of medically treated versus surgically treated primary open-angle glaucoma (POAG) patients attending Lagos University Teaching Hospital, Lagos, Nigeria.

Methods: The study was a hospital-based, comparative cross-sectional study. Consecutive consenting POAG participants who met the inclusion criteria were recruited until the sample size was achieved. QoL of all participants was assessed using the glaucoma QoL-15 and National Eye Institute Visual Function Questionnaire-25 (NEI-VFQ-25) questionnaires. Analysis was done using the IBM statistical package for the social sciences version 25.0.

Results: The study involved 81 participants who were only on medical treatment for POAG and 81 age- and sex-matched POAG participants who had trabeculectomy surgery. Surgically treated participants had a lower mean intraocular pressure 11.68 mmHg when compared to the medically treated participants 14.82 mmHg. Medically treated participants however had a better overall mean glaucoma QoL using the glaucoma QoL-15 (medical 34.36 ± 10.4, surgical 39.11 ± 13.9 P = 0.015) and NEI-VFQ-25 questionnaires (medical 68.32 ± 15.0, surgical 62.44 ± 18.8 P = 0.029). Controlling for the severity of glaucoma using the glaucoma QoL-15 questionnaire, medically treated participants had a better QoL only among participants with severe POAG (medical 49.13 ± 5.9, surgical 54.06 ± 4.6 P = 0.003). While using the NEI-VFQ-25 questionnaire, medically treated participants had a significantly better QoL only among participants with moderate (medical 74.70 ± 6.6, surgical 67.07 ± 15.6 P = 0.012) and severe POAG (medical 54.52 ± 6.3, surgical 45.51 ± 10.0 P = 0.004).

Conclusion: The study demonstrated that although participants that had trabeculectomy had a lower mean intraocular pressure, their overall mean QoL was reduced compared to the medically treated participants.

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来源期刊

Middle East African Journal of Ophthalmology OPHTHALMOLOGY-

CiteScore

1.40

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0.00%

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期刊介绍： The Middle East African Journal of Ophthalmology (MEAJO), published four times per year in print and online, is an official journal of the Middle East African Council of Ophthalmology (MEACO). It is an international, peer-reviewed journal whose mission includes publication of original research of interest to ophthalmologists in the Middle East and Africa, and to provide readers with high quality educational review articles from world-renown experts. MEAJO, previously known as Middle East Journal of Ophthalmology (MEJO) was founded by Dr Akef El Maghraby in 1993.