Jing Liu, Hongye Peng, Che Wang, Yutong Wang, Rongrui Wang, Jixiang Liu, Tianhui Zhou, Shukun Yao
{"title":"代谢功能障碍相关性脂肪肝严重程度与血清尿酸/肌酐比值的相关性","authors":"Jing Liu, Hongye Peng, Che Wang, Yutong Wang, Rongrui Wang, Jixiang Liu, Tianhui Zhou, Shukun Yao","doi":"10.1155/2023/6928117","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>As one of the most common chronic liver diseases, metabolic dysfunction-associated fatty liver disease (MAFLD) had different prognoses between mild and moderate-severe levels. Serum uric acid to serum creatinine ratio (sUA/Cr) can reflect the overall metabolic status of the body. To explore a convenient indicator to screen MAFLD and distinguish the severity of the disease, this study analyzed the correlation between sUA/Cr and the severity of MAFLD.</p><p><strong>Methods: </strong>228 participants were enrolled and divided into 2 groups, including mild MAFLD and non-MAFLD group and moderate-severe MAFLD group, based on liver/spleen computed tomography (CT) ratios. The correlations between sUA/Cr and the severity of MAFLD were analyzed by logistic and linear regression. Receiver operating characteristics (ROCs) analyzed the predictive ability of sUA/Cr for the severity of MAFLD expressed by the area under curve (AUC).</p><p><strong>Results: </strong>The level of sUA/Cr was higher in themoderate-severe MAFLD group than mild MAFLD and non-MAFLD group (6.14 ± 1.55 vs. 5.51 ± 1.19, <i>P</i> = 0.008). After adjustment for confounders, the correlation analysis showed that patients with elevated sUA/Cr had a higher risk of moderate-severe MAFLD (OR: 1.350, <i>P</i> = 0.036). A higher sUA/Cr level was associated with lower liver CT values (<i>β</i> = -0.133, <i>P</i> = 0.039) and liver/spleen CT ratio (<i>β</i> = -0.154, <i>P</i> = 0.016). sUA/Cr had the ability to discriminate the severity of MAFLD (AUC: 0.623).</p><p><strong>Conclusion: </strong>sUA/Cr was positively associated with the risk of moderate-severe MAFLD and had the predictive ability to discriminate the moderate-severe MAFLD from mild MAFLD and non-MAFLD. The sUA/Cr level was suggested to be monitored and controlled in the screening and treatment of MAFLD.</p>","PeriodicalId":13966,"journal":{"name":"International Journal of Endocrinology","volume":null,"pages":null},"PeriodicalIF":2.3000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9859690/pdf/","citationCount":"1","resultStr":"{\"title\":\"Correlation between the Severity of Metabolic Dysfunction-Associated Fatty Liver Disease and Serum Uric Acid to Serum Creatinine Ratio.\",\"authors\":\"Jing Liu, Hongye Peng, Che Wang, Yutong Wang, Rongrui Wang, Jixiang Liu, Tianhui Zhou, Shukun Yao\",\"doi\":\"10.1155/2023/6928117\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>As one of the most common chronic liver diseases, metabolic dysfunction-associated fatty liver disease (MAFLD) had different prognoses between mild and moderate-severe levels. Serum uric acid to serum creatinine ratio (sUA/Cr) can reflect the overall metabolic status of the body. To explore a convenient indicator to screen MAFLD and distinguish the severity of the disease, this study analyzed the correlation between sUA/Cr and the severity of MAFLD.</p><p><strong>Methods: </strong>228 participants were enrolled and divided into 2 groups, including mild MAFLD and non-MAFLD group and moderate-severe MAFLD group, based on liver/spleen computed tomography (CT) ratios. The correlations between sUA/Cr and the severity of MAFLD were analyzed by logistic and linear regression. Receiver operating characteristics (ROCs) analyzed the predictive ability of sUA/Cr for the severity of MAFLD expressed by the area under curve (AUC).</p><p><strong>Results: </strong>The level of sUA/Cr was higher in themoderate-severe MAFLD group than mild MAFLD and non-MAFLD group (6.14 ± 1.55 vs. 5.51 ± 1.19, <i>P</i> = 0.008). After adjustment for confounders, the correlation analysis showed that patients with elevated sUA/Cr had a higher risk of moderate-severe MAFLD (OR: 1.350, <i>P</i> = 0.036). A higher sUA/Cr level was associated with lower liver CT values (<i>β</i> = -0.133, <i>P</i> = 0.039) and liver/spleen CT ratio (<i>β</i> = -0.154, <i>P</i> = 0.016). sUA/Cr had the ability to discriminate the severity of MAFLD (AUC: 0.623).</p><p><strong>Conclusion: </strong>sUA/Cr was positively associated with the risk of moderate-severe MAFLD and had the predictive ability to discriminate the moderate-severe MAFLD from mild MAFLD and non-MAFLD. The sUA/Cr level was suggested to be monitored and controlled in the screening and treatment of MAFLD.</p>\",\"PeriodicalId\":13966,\"journal\":{\"name\":\"International Journal of Endocrinology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9859690/pdf/\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Endocrinology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1155/2023/6928117\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Endocrinology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1155/2023/6928117","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
引用次数: 1
摘要
目的:代谢功能障碍相关脂肪性肝病(MAFLD)是最常见的慢性肝病之一,其预后在轻度和中重度水平上存在差异。血清尿酸与血清肌酐比值(sUA/Cr)可以反映机体的整体代谢状态。为了探索一种方便筛选MAFLD和区分疾病严重程度的指标,本研究分析sUA/Cr与MAFLD严重程度的相关性。方法:228例受试者根据肝脾CT (computed tomography, CT)比值分为轻度、非MAFLD组和中重度MAFLD组。采用logistic回归和线性回归分析sUA/Cr与MAFLD严重程度的相关性。受试者工作特征(roc)分析sUA/Cr对曲线下面积(AUC)表示的MAFLD严重程度的预测能力。结果:中重度MAFLD组的sUA/Cr水平高于轻度MAFLD组和非MAFLD组(6.14±1.55∶5.51±1.19,P = 0.008)。校正混杂因素后,相关分析显示,sUA/Cr升高的患者发生中重度MAFLD的风险更高(OR: 1.350, P = 0.036)。较高的sUA/Cr水平与较低的肝脏CT值(β = -0.133, P = 0.039)和肝脾CT比(β = -0.154, P = 0.016)相关。sUA/Cr能够区分mld的严重程度(AUC: 0.623)。结论:sUA/Cr与中重度MAFLD发生风险呈正相关,具有区分中重度MAFLD、轻度MAFLD和非MAFLD的预测能力。建议监测和控制sUA/Cr水平,以筛查和治疗mald。
Correlation between the Severity of Metabolic Dysfunction-Associated Fatty Liver Disease and Serum Uric Acid to Serum Creatinine Ratio.
Purpose: As one of the most common chronic liver diseases, metabolic dysfunction-associated fatty liver disease (MAFLD) had different prognoses between mild and moderate-severe levels. Serum uric acid to serum creatinine ratio (sUA/Cr) can reflect the overall metabolic status of the body. To explore a convenient indicator to screen MAFLD and distinguish the severity of the disease, this study analyzed the correlation between sUA/Cr and the severity of MAFLD.
Methods: 228 participants were enrolled and divided into 2 groups, including mild MAFLD and non-MAFLD group and moderate-severe MAFLD group, based on liver/spleen computed tomography (CT) ratios. The correlations between sUA/Cr and the severity of MAFLD were analyzed by logistic and linear regression. Receiver operating characteristics (ROCs) analyzed the predictive ability of sUA/Cr for the severity of MAFLD expressed by the area under curve (AUC).
Results: The level of sUA/Cr was higher in themoderate-severe MAFLD group than mild MAFLD and non-MAFLD group (6.14 ± 1.55 vs. 5.51 ± 1.19, P = 0.008). After adjustment for confounders, the correlation analysis showed that patients with elevated sUA/Cr had a higher risk of moderate-severe MAFLD (OR: 1.350, P = 0.036). A higher sUA/Cr level was associated with lower liver CT values (β = -0.133, P = 0.039) and liver/spleen CT ratio (β = -0.154, P = 0.016). sUA/Cr had the ability to discriminate the severity of MAFLD (AUC: 0.623).
Conclusion: sUA/Cr was positively associated with the risk of moderate-severe MAFLD and had the predictive ability to discriminate the moderate-severe MAFLD from mild MAFLD and non-MAFLD. The sUA/Cr level was suggested to be monitored and controlled in the screening and treatment of MAFLD.
期刊介绍:
International Journal of Endocrinology is a peer-reviewed, Open Access journal that provides a forum for scientists and clinicians working in basic and translational research. The journal publishes original research articles, review articles, and clinical studies that provide insights into the endocrine system and its associated diseases at a genomic, molecular, biochemical and cellular level.