糖皮质激素诱发骨质疏松症的发病机制。

IF 9.3 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Cytokine & Growth Factor Reviews Pub Date : 2023-04-01 DOI:10.1016/j.cytogfr.2023.03.002
Meng Chen , Wenyu Fu , Huiyun Xu , Chuan-ju Liu
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引用次数: 6

摘要

糖皮质激素(GC)是治疗各种炎症和自身免疫性疾病的最常用药物之一。然而,高剂量和长期使用GC会导致多种不良反应,特别是糖皮质激素诱导的骨质疏松症(GIO)。过量的GC对骨细胞(包括成骨细胞、破骨细胞和骨细胞)产生有害影响,导致骨形成和吸收受损。外源GC的作用被认为是强烈的细胞类型和剂量依赖性的。GC过量抑制成骨细胞的增殖和分化,增强成骨细胞和骨细胞的凋亡,最终导致骨形成减少。GC过量对破骨细胞的影响主要包括破骨细胞生成增强、成熟破骨细胞寿命和数量增加以及破骨细胞凋亡减少,从而导致骨吸收增加。此外,GC对骨细胞的分泌有影响,从而干扰成骨细胞和破骨细胞的生成过程。这篇综述及时更新和总结了GIO领域的最新发现,特别关注外源GC对骨细胞的影响以及在GC过量的情况下它们之间的串扰。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Pathogenic mechanisms of glucocorticoid-induced osteoporosis

Glucocorticoid (GC) is one of the most prescribed medicines to treat various inflammatory and autoimmune diseases. However, high doses and long-term use of GCs lead to multiple adverse effects, particularly glucocorticoid-induced osteoporosis (GIO). Excessive GCs exert detrimental effects on bone cells, including osteoblasts, osteoclasts, and osteocytes, leading to impaired bone formation and resorption. The actions of exogenous GCs are considered to be strongly cell-type and dose dependent. GC excess inhibits the proliferation and differentiation of osteoblasts and enhances the apoptosis of osteoblasts and osteocytes, eventually contributing to reduced bone formation. Effects of GC excess on osteoclasts mainly include enhanced osteoclastogenesis, increased lifespan and number of mature osteoclasts, and diminished osteoclast apoptosis, which result in increased bone resorption. Furthermore, GCs have an impact on the secretion of bone cells, subsequently disturbing the process of osteoblastogenesis and osteoclastogenesis. This review provides timely update and summary of recent discoveries in the field of GIO, with a particular focus on the effects of exogenous GCs on bone cells and the crosstalk among them under GC excess.

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来源期刊
Cytokine & Growth Factor Reviews
Cytokine & Growth Factor Reviews 生物-生化与分子生物学
CiteScore
21.10
自引率
1.50%
发文量
61
审稿时长
22 days
期刊介绍: Cytokine & Growth Factor Reviews is a leading publication that focuses on the dynamic fields of growth factor and cytokine research. Our journal offers a platform for authors to disseminate thought-provoking articles such as critical reviews, state-of-the-art reviews, letters to the editor, and meeting reviews. We aim to cover important breakthroughs in these rapidly evolving areas, providing valuable insights into the multidisciplinary significance of cytokines and growth factors. Our journal spans various domains including signal transduction, cell growth and differentiation, embryonic development, immunology, tumorigenesis, and clinical medicine. By publishing cutting-edge research and analysis, we aim to influence the way researchers and experts perceive and understand growth factors and cytokines. We encourage novel expressions of ideas and innovative approaches to organizing content, fostering a stimulating environment for knowledge exchange and scientific advancement.
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