用浸泡氟康唑的珠子治疗猪尾猕猴(Macaca nemestrina)由球孢子菌引起的骨髓炎。

IF 1.3 4区 农林科学 Q2 VETERINARY SCIENCES Comparative medicine Pub Date : 2022-08-01 Epub Date: 2022-07-14 DOI:10.30802/AALAS-CM-21-000107
Charlotte E Hotchkiss, Dean A Jeffery, Keith W Vogel
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引用次数: 0

摘要

一只 3 岁大的雄性猪尾猕猴(Macaca nemestrina)因左前臂远端肿胀和手臂活动能力下降而前来就诊。这只猕猴曾在亚利桑那州的一家室内-室外设施饲养,发病前 2 个月被转移到华盛顿州的一家室内设施。根据X光片和球孢子菌滴度,初步诊断为桡骨真菌性骨髓炎。除了全身抗真菌治疗外,还进行了骨质病变清创手术,并植入了浸渍有抗真菌剂氟康唑的聚甲基丙烯酸甲酯微珠。对剥离物进行组织学检查后,确诊为真菌性骨髓炎。手术后临床症状有所改善,表现为体重增加和球孢子菌滴度下降。在第二次手术中取出了微珠,骨质病变完全消退。在继续接受氟康唑全身治疗后,这只猴子保持健康,没有再出现骨髓炎的迹象。球孢子菌是一种新出现的病原体,对人类和动物都会造成严重的发病率和死亡率。骨感染可能对全身治疗产生抗药性,而植入浸泡氟康唑的微珠可能为真菌性骨髓炎提供一种成功的治疗策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Use of Fluconazole-impregnated Beads to Treat Osteomyelitis Caused by Coccidioides in a Pigtailed Macaque (Macaca nemestrina).

A 3-y-old male pigtailed macaque (Macaca nemestrina) presented for swelling of the left distal forearm and decreased use of the arm. The monkey had been raised at an indoor-outdoor facility in Arizona and transferred to an indoor facility in Washington 2 mo prior to presentation. A preliminary diagnosis of fungal osteomyelitis of the radius was made based on radiographs and Coccidioides titers. In addition to systemic antifungal treatment, surgery was performed to debride the bony lesion and implant polymethylmethacrylate beads impregnanted with the anti-fungal fluconazole. Histologic examination of the debrided material confirmed the diagnosis of fungal osteomyelitis. The surgical procedure resulted in clinical improvement, as evidenced by weight gain and decreased Coccidioides titers. The beads were removed in a second surgery, and the bony lesion completely resolved. With continued systemic fluconazole treatment, the monkey remained healthy with no further evidence of osteomyelitis. Coccidioides is an emerging pathogen that causes significant morbidity and mortality in both humans and animals. Bone infections can be resistant to systemic treatment, and the implantation of fluconazoleimpregnated beads may offer a successful treatment strategy for fungal osteomyelitis.

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来源期刊
Comparative medicine
Comparative medicine 医学-动物学
CiteScore
1.90
自引率
0.00%
发文量
71
审稿时长
6-12 weeks
期刊介绍: Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.
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