横纹肌肉瘤质子放化疗后晚期牙齿毒性:一个儿科病例报告。

Emma Foster-Thomas, Marianne Aznar, Daniel Indelicato, Shermaine Pan, Eunji Hwang, Peter Sitch, Keith Horner, Ed Smith, Simona Gaito
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引用次数: 1

摘要

目的:放射治疗是儿童癌症幸存者口腔和牙列不良后遗症的独立危险因素。然而,放射治疗后的牙齿毒性通常被低估,并且很少有关于质子束治疗(PBT)后牙齿发育紊乱的公开数据。我们报告了一名横纹肌肉瘤患者接受PBT和化疗治疗后8年的长期临床和牙科放射学表现。材料和方法:质子海外计划(POP)中接受PBT治疗的患者的临床随访数据存储在国家数据库中,并由克里斯蒂NHS PBT中心的专门结果部门管理。本病例报告是从该数据库中儿童头颈癌患者数据的提取和分析中确定的,用于服务评估项目。结果:该患者治疗时年龄为3.5岁,恒牙发育严重,治疗结束后3.5年首次观察到牙发育异常。PBT对上颌骨的平均剂量为30 Gy(RBE = 1.1),对下颌骨的平均剂量为25.9 Gy(RBE = 1.1)。结论:尽管该地区的剂量低于文献中建议的阈值,但该儿科患者发生了明显的牙齿发育异常。需要改进牙齿毒性的描述和上颌和下颌骨的常规轮廓来关联剂量学数据。在确定牙齿毒性的剂量阈值之前,年轻患者的牙齿剂量应尽可能低。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Late Dental Toxicities After Proton Chemoradiation for Rhabdomyosarcoma: A Pediatric Case Report.

Purpose: Radiation therapy is an independent risk factor for adverse sequelae to the oral cavity and dentition in childhood cancer survivors. However, dental toxicities after radiation therapy often are underreported and there are minimal published data on disturbances in tooth development after proton beam therapy (PBT). We present the long-term clinical and radiographic dental findings 8 years after treatment completion for a patient treated with PBT and chemotherapy for rhabdomyosarcoma.

Materials and methods: Clinical follow-up data of patients treated with PBT within the Proton Overseas Programme (POP) is stored in a National Database and curated by a dedicated outcomes unit at the Christie NHS PBT center. This case report was identified from the extraction and analysis of data for pediatric head and neck cancer patients in this database for a service evaluation project.

Results: The permanent dentition in this patient aged 3.5 years at the time of treatment was severely affected with abnormal dental development first observed 3.5 years after treatment completion. PBT delivered mean doses of 30 Gy(RBE = 1.1) to the maxilla and 25.9 Gy(RBE = 1.1) to the mandible.

Conclusion: Significant dental development abnormalities occurred in this pediatric patient, despite doses in areas being lower than the proposed thresholds in the literature. Improved descriptions of dental toxicities and routine contouring of the maxilla and mandible are needed to correlate dosimetric data. The dose to teeth should be kept as low as reasonably possible in younger patients until the dose thresholds for dental toxicities are known.

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来源期刊
International Journal of Particle Therapy
International Journal of Particle Therapy Medicine-Radiology, Nuclear Medicine and Imaging
CiteScore
3.70
自引率
5.90%
发文量
23
审稿时长
20 weeks
期刊最新文献
Impact of COVID-19 Pandemic on Carbon-Ion Radiation Therapy in Japan: A Japanese National Registry Study. Vaginal Mucosal Melanoma Cell Activation in Response to Photon or Carbon Ion Irradiation. Navigating a New Frontier: Evaluating Leadless Pacemakers in Proton Therapy. Cardiac Conduction System as an OAR in Radiation Therapy: Doses to SA/AV Nodes and Their Reduction. Value of Carbon-Ion Radiation Therapy for Breast Cancer.
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