炎症相关高血压的表观遗传机制

IF 3.9 2区 医学 Q1 PERIPHERAL VASCULAR DISEASE Current Hypertension Reports Pub Date : 2022-11-01 DOI:10.1007/s11906-022-01214-4
Vinícius Augusto Simão, León Ferder, Walter Manucha, Luiz Gustavo A Chuffa
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引用次数: 5

摘要

综述目的:本文综述了炎症在血管损伤中的作用,重点介绍了炎症诱发高血压的表观遗传机制。近期研究发现:高血压的炎症是一种复杂的疾病,与免疫细胞产生炎症介质、氧化应激增强以及血管平滑肌细胞和内皮细胞的组织重塑有关。细胞过程很多,包括炎性体组装和细胞衰老,这可能涉及线粒体功能障碍、自噬、DNA损伤反应、生态失调等。最近,一系列非编码rna,主要是microRNAs,被描述为在炎症小体相关高血压的调节中具有表观遗传作用,成为一种有前景的治疗策略。虽然有多种药物可以有效调节炎症相关性高血压,但为了治疗甚至预防疾病的发生,需要更深入地了解控制血管恶化背后的表观遗传事件。
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Epigenetic Mechanisms Involved in Inflammaging-Associated Hypertension.

Purpose of review: This review summarizes the involvement of inflammaging in vascular damage with focus on the epigenetic mechanisms by which inflammaging-induced hypertension is triggered.

Recent findings: Inflammaging in hypertension is a complex condition associated with the production of inflammatory mediators by the immune cells, enhancement of oxidative stress, and tissue remodeling in vascular smooth muscle cells and endothelial cells. Cellular processes are numerous, including inflammasome assembly and cell senescence which may involve mitochondrial dysfunction, autophagy, DNA damage response, dysbiosis, and many others. More recently, a series of noncoding RNAs, mainly microRNAs, have been described as possessing epigenetic actions on the regulation of inflammasome-related hypertension, emerging as a promising therapeutic strategy. Although there are a variety of pharmacological agents that effectively regulate inflammaging-related hypertension, a deeper understanding of the epigenetic events behind the control of vessel deterioration is needed for the treatment or even to prevent the disease onset.

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来源期刊
Current Hypertension Reports
Current Hypertension Reports 医学-外周血管病
CiteScore
10.50
自引率
0.00%
发文量
65
审稿时长
6-12 weeks
期刊介绍: This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of hypertension. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as antihypertensive therapies, associated metabolic disorders, and therapeutic trials. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.
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