运动神经元疾病中的小胶质细胞:近10年的信号证据

IF 2.7 4区医学 Q2 DEVELOPMENTAL BIOLOGY Developmental Neurobiology Pub Date : 2022-10-29 DOI:10.1002/dneu.22905

Min-Jia Wang, Lu Kang, Yao-Zheng Wang, Bi-Ru Yang, Chun Zhang, Yu-Feng Lu, Liang Kang

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引用次数: 7

摘要

运动神经元疾病(MND)，包括肌萎缩性侧索硬化症、脊髓性肌萎缩症等，涉及上或下运动神经元选择性丧失，其特征是神经变性和神经炎症，并伴有小胶质细胞。我们总结了与小胶质细胞相关的通路和关键介质，如fractalkine信号、purinergic信号、NF-κB信号、p38 MAPK信号、TREM2-APOE信号、ROCK信号、C1q信号和离子通道等，它们参与了小胶质细胞的激活、增殖和炎症。本文旨在确定与小胶质细胞相关的分子靶点，并探讨基于该靶点的MND的潜在治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Microglia in motor neuron disease: Signaling evidence from last 10 years

Motor neuron disease (MND), including amyotrophic lateral sclerosis, spinal muscular atrophy and others, involved the upper or lower motor neurons selective loss, is characterized by neurodegeneration and neuroinflammation, in conjunction with microglia. We summarized that pathways and key mediators are associated with microglia, such as fractalkine signaling, purinergic signaling, NF-κB signaling, p38 MAPK signaling, TREM2-APOE signaling, ROCK signaling, C1q signaling, and Ion channel, which are involved in the activation, proliferation, and inflammation of microglia. This review aims to identify the microglia-related molecular target and explore potential treatment strategies for MND based on that target.

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来源期刊

Developmental Neurobiology 生物-发育生物学

CiteScore

6.50

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： Developmental Neurobiology (previously the Journal of Neurobiology ) publishes original research articles on development, regeneration, repair and plasticity of the nervous system and on the ontogeny of behavior. High quality contributions in these areas are solicited, with an emphasis on experimental as opposed to purely descriptive work. The Journal also will consider manuscripts reporting novel approaches and techniques for the study of the development of the nervous system as well as occasional special issues on topics of significant current interest. We welcome suggestions on possible topics from our readers.

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