作为研究大脑衰老和再生的体内模型的鱼视觉系统。

IF 5.4 Q1 GERIATRICS & GERONTOLOGY NPJ Aging and Mechanisms of Disease Pub Date : 2021-08-17 DOI:10.1038/s41514-021-00077-4
Sophie Vanhunsel, Steven Bergmans, An Beckers, Isabelle Etienne, Jolien Van Houcke, Eve Seuntjens, Lut Arckens, Lies De Groef, Lieve Moons
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引用次数: 19

摘要

在世界范围内,人们越来越老,不幸的是,这种寿命延长也导致了与年龄相关的神经退行性疾病的患病率增加,导致老年人的生活质量下降。年龄相关的神经病通常包括导致痴呆的疾病(阿尔茨海默病和帕金森病),以及青光眼和年龄相关性黄斑变性等眼部疾病。尽管许多研究试图揭示衰老过程及其与神经退行性变和功能衰退的关系,但实现健康的大脑衰老仍然是一个挑战。非洲绿松鱼(Nothobranchius furzeri)是据报道寿命最短的脊椎动物,可以人工饲养,并表现出许多人类衰老的特征,这使其成为一种非常有前途的生物老年学模型。由于视力下降是衰老的重要标志,也是许多神经退行性疾病的表现,我们对这种鱼衰老的视觉系统进行了全面的表征。我们的研究揭示了鱼视网膜和大脑的几个衰老特征,这些特征最终导致视觉表现下降。此外,我们发现有证据表明,在老年的鱼视网膜中发生了神经退行性事件。总之,我们介绍了快速衰老的killifish的视觉系统,作为了解脊椎动物中枢神经系统衰老的细胞和分子机制的一个有价值的模型。这些发现为靶点验证以及确保健康衰老的恢复活力或神经保护疗法的药物发现提出了建议。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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The killifish visual system as an in vivo model to study brain aging and rejuvenation.

Worldwide, people are getting older, and this prolonged lifespan unfortunately also results in an increased prevalence of age-related neurodegenerative diseases, contributing to a diminished life quality of elderly. Age-associated neuropathies typically include diseases leading to dementia (Alzheimer's and Parkinson's disease), as well as eye diseases such as glaucoma and age-related macular degeneration. Despite many research attempts aiming to unravel aging processes and their involvement in neurodegeneration and functional decline, achieving healthy brain aging remains a challenge. The African turquoise killifish (Nothobranchius furzeri) is the shortest-lived reported vertebrate that can be bred in captivity and displays many of the aging hallmarks that have been described for human aging, which makes it a very promising biogerontology model. As vision decline is an important hallmark of aging as well as a manifestation of many neurodegenerative diseases, we performed a comprehensive characterization of this fish's aging visual system. Our work reveals several aging hallmarks in the killifish retina and brain that eventually result in a diminished visual performance. Moreover, we found evidence for the occurrence of neurodegenerative events in the old killifish retina. Altogether, we introduce the visual system of the fast-aging killifish as a valuable model to understand the cellular and molecular mechanisms underlying aging in the vertebrate central nervous system. These findings put forward the killifish for target validation as well as drug discovery for rejuvenating or neuroprotective therapies ensuring healthy aging.

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来源期刊
NPJ Aging and Mechanisms of Disease
NPJ Aging and Mechanisms of Disease Medicine-Geriatrics and Gerontology
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审稿时长
8 weeks
期刊介绍: npj Aging and Mechanisms of Disease is an online open access journal that provides a forum for the world’s most important research in the fields of aging and aging-related disease. The journal publishes papers from all relevant disciplines, encouraging those that shed light on the mechanisms behind aging and the associated diseases. The journal’s scope includes, but is not restricted to, the following areas (not listed in order of preference): • cellular and molecular mechanisms of aging and aging-related diseases • interventions to affect the process of aging and longevity • homeostatic regulation and aging • age-associated complications • translational research into prevention and treatment of aging-related diseases • mechanistic bases for epidemiological aspects of aging-related disease.
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