评估益生菌对海湾战争退伍军人肠易激综合征影响的随机双盲安慰剂对照试验》(Randomized, Double-Blind Placebo-Controlled Trial to Assess the Effect of Probiotics on Irritable Bowel Syndrome in Veterans with Gulf War Illness.
Ashok K Tuteja, Nicholas J Talley, Maureen A Murtaugh, Catherine M Loc-Carrillo, Gregory J Stoddard, Gary L Anderson
{"title":"评估益生菌对海湾战争退伍军人肠易激综合征影响的随机双盲安慰剂对照试验》(Randomized, Double-Blind Placebo-Controlled Trial to Assess the Effect of Probiotics on Irritable Bowel Syndrome in Veterans with Gulf War Illness.","authors":"Ashok K Tuteja, Nicholas J Talley, Maureen A Murtaugh, Catherine M Loc-Carrillo, Gregory J Stoddard, Gary L Anderson","doi":"10.12788/fp.0322","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Many veterans who served in Operation Desert Storm (August 1990 to March 1991) experienced a complex of symptoms of unknown etiology called Gulf War illness (GWI), which significantly impacts the health and quality of life (QOL) and may have contributed to irritable bowel syndrome (IBS).</p><p><strong>Methods: </strong>We performed a prospective, double-blind placebocontrolled study to determine the efficacy of the multistrain De Simone Formulation probiotic containing 8 strains of bacteria on symptoms of IBS and GWI. Veterans of Operation Desert Storm who had IBS and ≥ 2 nonintestinal symptoms of GWI were included. The primary study endpoint was change in bowel symptom score. The secondary endpoints were mean change in symptoms, QOL, and extra-intestinal and posttraumatic stress disorder (PTSD) symptoms.</p><p><strong>Results: </strong>A total of 101 Gulf War veterans with IBS and GWI were screened at the Veteran Affairs Medical Center in Salt Lake City, Utah. The study was completed by 53 veterans; 47 (89%) were male with a mean (SD) age of 55 (8) years. The probiotic did not improve IBS symptoms or other extra-intestinal symptoms common to IBS and GWI.</p><p><strong>Conclusions: </strong>Our study did not demonstrate statistically significant improvement in IBS symptoms or QOL after treatment with the probiotic. We also did not find any improvement in symptoms of GWI or PTSD.</p>","PeriodicalId":73021,"journal":{"name":"Federal practitioner : for the health care professionals of the VA, DoD, and PHS","volume":"39 10","pages":"410-417"},"PeriodicalIF":0.0000,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9896367/pdf/fp-39-10-410.pdf","citationCount":"0","resultStr":"{\"title\":\"Randomized, Double-Blind Placebo-Controlled Trial to Assess the Effect of Probiotics on Irritable Bowel Syndrome in Veterans With Gulf War Illness.\",\"authors\":\"Ashok K Tuteja, Nicholas J Talley, Maureen A Murtaugh, Catherine M Loc-Carrillo, Gregory J Stoddard, Gary L Anderson\",\"doi\":\"10.12788/fp.0322\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Many veterans who served in Operation Desert Storm (August 1990 to March 1991) experienced a complex of symptoms of unknown etiology called Gulf War illness (GWI), which significantly impacts the health and quality of life (QOL) and may have contributed to irritable bowel syndrome (IBS).</p><p><strong>Methods: </strong>We performed a prospective, double-blind placebocontrolled study to determine the efficacy of the multistrain De Simone Formulation probiotic containing 8 strains of bacteria on symptoms of IBS and GWI. Veterans of Operation Desert Storm who had IBS and ≥ 2 nonintestinal symptoms of GWI were included. The primary study endpoint was change in bowel symptom score. The secondary endpoints were mean change in symptoms, QOL, and extra-intestinal and posttraumatic stress disorder (PTSD) symptoms.</p><p><strong>Results: </strong>A total of 101 Gulf War veterans with IBS and GWI were screened at the Veteran Affairs Medical Center in Salt Lake City, Utah. The study was completed by 53 veterans; 47 (89%) were male with a mean (SD) age of 55 (8) years. The probiotic did not improve IBS symptoms or other extra-intestinal symptoms common to IBS and GWI.</p><p><strong>Conclusions: </strong>Our study did not demonstrate statistically significant improvement in IBS symptoms or QOL after treatment with the probiotic. We also did not find any improvement in symptoms of GWI or PTSD.</p>\",\"PeriodicalId\":73021,\"journal\":{\"name\":\"Federal practitioner : for the health care professionals of the VA, DoD, and PHS\",\"volume\":\"39 10\",\"pages\":\"410-417\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9896367/pdf/fp-39-10-410.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Federal practitioner : for the health care professionals of the VA, DoD, and PHS\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.12788/fp.0322\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2022/10/12 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Federal practitioner : for the health care professionals of the VA, DoD, and PHS","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.12788/fp.0322","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/10/12 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
背景:许多参加过 "沙漠风暴 "行动(1990 年 8 月至 1991 年 3 月)的退伍军人都经历过一种病因不明的综合症状,即海湾战争病(GWI),它严重影响了退伍军人的健康和生活质量(QOL),并可能导致肠易激综合征(IBS):我们进行了一项前瞻性双盲安慰剂对照研究,以确定含有 8 种菌株的多菌株 De Simone 配方益生菌对肠易激综合征和海湾战争病症状的疗效。研究对象包括参加过沙漠风暴行动、患有肠易激综合征且≥两种非肠道症状的退伍军人。研究的主要终点是肠道症状评分的变化。次要终点是症状、QOL、肠道外症状和创伤后应激障碍(PTSD)症状的平均变化:犹他州盐湖城退伍军人事务医疗中心共筛查了 101 名患有肠易激综合征和 GWI 的海湾战争退伍军人。53 名退伍军人完成了研究,其中 47 人(89%)为男性,平均(标清)年龄为 55(8)岁。益生菌并未改善肠易激综合征症状或其他肠易激综合征和GWI常见的肠外症状:结论:我们的研究表明,使用益生菌治疗后,肠易激综合征症状或 QOL 没有得到统计学意义上的明显改善。结论:我们的研究没有发现使用益生菌治疗后,肠易激综合征症状或 QOL 有统计学意义的改善,也没有发现 GWI 或创伤后应激障碍症状有任何改善。
Randomized, Double-Blind Placebo-Controlled Trial to Assess the Effect of Probiotics on Irritable Bowel Syndrome in Veterans With Gulf War Illness.
Background: Many veterans who served in Operation Desert Storm (August 1990 to March 1991) experienced a complex of symptoms of unknown etiology called Gulf War illness (GWI), which significantly impacts the health and quality of life (QOL) and may have contributed to irritable bowel syndrome (IBS).
Methods: We performed a prospective, double-blind placebocontrolled study to determine the efficacy of the multistrain De Simone Formulation probiotic containing 8 strains of bacteria on symptoms of IBS and GWI. Veterans of Operation Desert Storm who had IBS and ≥ 2 nonintestinal symptoms of GWI were included. The primary study endpoint was change in bowel symptom score. The secondary endpoints were mean change in symptoms, QOL, and extra-intestinal and posttraumatic stress disorder (PTSD) symptoms.
Results: A total of 101 Gulf War veterans with IBS and GWI were screened at the Veteran Affairs Medical Center in Salt Lake City, Utah. The study was completed by 53 veterans; 47 (89%) were male with a mean (SD) age of 55 (8) years. The probiotic did not improve IBS symptoms or other extra-intestinal symptoms common to IBS and GWI.
Conclusions: Our study did not demonstrate statistically significant improvement in IBS symptoms or QOL after treatment with the probiotic. We also did not find any improvement in symptoms of GWI or PTSD.