唐氏综合征的短暂性骨髓异常:泰国单一三级中心的长期随访经验。

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2023-03-01 DOI:10.1080/08880018.2022.2075501

Thirachit Chotsampancharoen, Shevachut Chavananon, Pornpun Sripornsawan, Natsaruth Songthawee, Edward B McNeil

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引用次数: 2

摘要

短暂性骨髓增生异常(TAM)是一种发生在唐氏综合征(DS)婴儿中的独特疾病，大多数患者会自发缓解。本研究旨在评估泰国某三级医疗中心TAM的发病率和预后。我们回顾了1993年6月至2019年10月期间诊断的997名DS患者的记录。在997例DS患者中，32例被诊断为TAM。TAM的发生率为3.2%，总生存率为87.5%。共有2/28的存活患者(7.1%)分别在2.1岁和4.5岁时发生AML-DS。与死亡相关的危险因素包括产妇多胎、败血症、皮肤出血、皮下结节、白细胞计数高、血红蛋白低和AST水平升高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Transient abnormal myelopoiesis in Down syndrome: Experience of long term follow up from a single tertiary center in Thailand.

Transient abnormal myelopoiesis (TAM) is a unique disease occurring in Down syndrome (DS) infants from which most patients have spontaneous remission. This study aimed to evaluate the incidence and outcomes of TAM in a tertiary center in Thailand. We reviewed the records of 997 DS patients diagnosed between June 1993 and October 2019. From the 997 DS patients, 32 had been diagnosed with TAM. The incidence of TAM was 3.2% and an overall survival rate of 87.5%. A total of 2/28 who survived (7.1%) subsequently developed AML-DS at the ages of 2.1 and 4.5 years, respectively. The risk factors related with death included maternal multiparity, sepsis, skin bleeding, subcutaneous nodules, high WBC count, low hemoglobin, and elevated AST level.Abbreviations.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.