应用亚脂素和亚脂素鉴别诊断浆液性卵巢肿瘤。

IF 1.6 4区生物学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Biotechnic & Histochemistry Pub Date : 2023-02-01 DOI:10.1080/10520295.2022.2135763

Miyase Mirzaoglu, Seyda Yavuzkir, Cetin Mirzaoglu, Nurdan Yurt, Adile Ferda Dagli, Sena Ozcan Yildirim, İbrahim Sahin, Suleyman Aydin

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引用次数: 3

摘要

Asprosin (ASP)和亚脂肪素是调节葡萄糖代谢的激素。ASP和亚脂肪素在浆液性卵巢肿瘤中的作用尚未研究。我们在30例卵巢良性浆液组织、30例交界性浆液组织、30例恶性浆液组织和30例对照组织中研究了亚脂肪素和阿斯丁蛋白的表达。我们研究了ASP和亚脂肪蛋白的免疫反应性，并采用ELISA法定量。ASP和亚脂肪素定位于正常卵巢组织的上皮部分;然而，在癌组织中，在实质区域检测到免疫反应性。卵巢组织生化分析显示，与对照组相比，ASP和亚脂肪素显著降低。我们认为ASP和亚脂肪素是区分浆液性良性、浆液性交界性和恶性卵巢癌的有希望的生物标志物候选人。

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Use of asprosin and subfatin for differential diagnosis of serous ovarian tumors.

Asprosin (ASP) and subfatin are hormones that regulate glucose metabolism. The role of ASP and subfatin in serous ovarian tumors has not been investigated. We investigated the expression of subfatin and asprosin in 30 serous benign, 30 serous borderline, 30 malignant and 30 control ovarian tissues. We investigated ASP and subfatin immunoreactivity and quantification was achieved using an ELISA method. ASP and subfatin were localized in the epithelial parts of normal ovarian tissues; however, in cancer tissues, immunoreactivity was detected in the parenchymal areas. Biochemical analysis of ovarian tissues revealed significantly decreased ASP and subfatin compared to the control. We propose that ASP and subfatin are promising candidates for biomarkers to distinguish serous benign, serous borderline and malignant ovarian cancers.

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来源期刊

Biotechnic & Histochemistry 生物-生物工程与应用微生物

CiteScore

3.40

自引率

6.20%

发文量

审稿时长

6-12 weeks

期刊介绍： Biotechnic & Histochemistry (formerly Stain technology) is the official publication of the Biological Stain Commission. The journal has been in continuous publication since 1926. Biotechnic & Histochemistry is an interdisciplinary journal that embraces all aspects of techniques for visualizing biological processes and entities in cells, tissues and organisms; papers that describe experimental work that employs such investigative methods are appropriate for publication as well. Papers concerning topics as diverse as applications of histochemistry, immunohistochemistry, in situ hybridization, cytochemical probes, autoradiography, light and electron microscopy, tissue culture, in vivo and in vitro studies, image analysis, cytogenetics, automation or computerization of investigative procedures and other investigative approaches are appropriate for publication regardless of their length. Letters to the Editor and review articles concerning topics of special and current interest also are welcome.