COVID-19疫苗接种引发的小纤维神经病：与表皮生长因子受体 3 自身抗体有关，静脉注射免疫球蛋白治疗后病情有所改善。

IF 0.6 Q4 CLINICAL NEUROLOGY Case Reports in Neurology Pub Date : 2023-01-27 eCollection Date: 2023-01-01 DOI:10.1159/000528566

Maria Mastropaolo, M Joshua Hasbani

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引用次数: 3

摘要

多个系列病例表明，急性冠状病毒病 2019（COVID-19）感染后会出现小纤维神经病。此外，一个大型病例证实，有报告称 COVID-19 疫苗会导致小纤维神经病。我们报告了一例接种 COVID-19 疫苗后确诊小纤维神经病的患者，其 FGFR3 抗体呈阳性。最近，有人探讨了静脉注射免疫球蛋白（IVIG）治疗假定的自身免疫性小纤维神经病的效果。据我们所知，这是第一例关于接种 COVID 疫苗引起的 FGFR3 相关小纤维神经病在注射 IVIG 后得到改善的公开病例报告，皮肤活检测得的小纤维密度恢复正常，同时患者的症状也得到明显改善。

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Small Fiber Neuropathy Triggered by COVID-19 Vaccination: Association with FGFR3 Autoantibodies and Improvement during Intravenous Immunoglobulin Treatment.

Multiple case series have demonstrated the emergence of small fiber neuropathy following acute coronavirus disease 2019 (COVID-19) infections. Further, one large case supports that the COVID-19 vaccine has been reported to result in small fiber neuropathy. We report a case of a patient with confirmed small fiber neuropathy post-COVID-19 vaccination with positive FGFR3 antibodies. The effect of intravenous immunoglobulin (IVIG) has been recently explored for treatment of presumed autoimmune small fiber neuropathy. To our knowledge, this is the first published case report of COVID vaccination-induced FGFR3-associated small fiber neuropathy improving in the context of IVIG administration as demonstrated by normalization of small fiber density measured by skin biopsy accompanied by marked improvement in the patient's symptoms.

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来源期刊

Case Reports in Neurology Medicine-Neurology (clinical)

CiteScore

1.50

自引率

0.00%

发文量

审稿时长

14 weeks

期刊介绍： This new peer-reviewed online-only journal publishes original case reports covering the entire spectrum of neurology. Clinicians and researchers are given a tool to disseminate their personal experience to a wider public as well as to review interesting cases encountered by colleagues all over the world. To complement the contributions supplementary material is welcomed. The reports are searchable according to the key words supplied by the authors; it will thus be possible to search across the entire growing collection of case reports with universally used terms, further facilitating the retrieval of specific information. Following the open access principle, the entire contents can be retrieved at no charge, guaranteeing easy access to this valuable source of anecdotal information at all times.