COVID-19:病毒变体的挑战。

IF 15.1 1区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL Annual review of medicine Pub Date : 2023-01-27 DOI:10.1146/annurev-med-042921-020956

Jana L Jacobs, Ghady Haidar, John W Mellors

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引用次数: 29

摘要

COVID-19大流行伴随着SARS-CoV-2的进化和病毒变体的出现，远远超出了最初的预期。已经出现了五种主要的变异(α、β、γ、δ和Omicron)，每一种都有独特的和重叠的氨基酸取代，这些取代影响了传播性、疾病严重程度以及对自然或疫苗诱导的免疫反应和单克隆抗体的易感性。最近的几个变种似乎已经进化出免疫逃避的特性，特别是在长期感染的情况下。追踪现有变异和监测新变异对于有效应对大流行至关重要。

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COVID-19: Challenges of Viral Variants.

The COVID-19 pandemic has been accompanied by SARS-CoV-2 evolution and emergence of viral variants that have far exceeded initial expectations. Five major variants of concern (Alpha, Beta, Gamma, Delta, and Omicron) have emerged, each having both unique and overlapping amino acid substitutions that have affected transmissibility, disease severity, and susceptibility to natural or vaccine-induced immune responses and monoclonal antibodies. Several of the more recent variants appear to have evolved properties of immune evasion, particularly in cases of prolonged infection. Tracking of existing variants and surveillance for new variants are critical for an effective pandemic response.

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来源期刊

Annual review of medicine 医学-医学：内科

CiteScore

24.90

自引率

0.00%

发文量

期刊介绍： The Annual Review of Medicine, which has been published since 1950, focuses on important advancements in diverse areas of medicine. These include AIDS/HIV, cardiology, clinical pharmacology, dermatology, endocrinology/metabolism, gastroenterology, genetics, immunology, infectious disease, neurology, oncology/hematology, pediatrics, psychiatry, pulmonology, reproductive medicine, and surgery. The journal's current volume has transitioned from a gated access model to an open access model through the Annual Reviews' Subscribe to Open program. All articles published in the journal are now available under a CC BY license.

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