急性淋巴细胞白血病儿童患者强化化疗期间急性并发症的观察:单中心经验。

IF 0.9 Q3 MEDICINE, GENERAL & INTERNAL Northern Clinics of Istanbul Pub Date : 2023-01-01 DOI:10.14744/nci.2022.47600
Ulku Miray Yildirim, Funda Tekkesin, Begum Sirin Koc, Selime Aydogdu, Fikret Asarcikli, Suar Caki Kilic
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引用次数: 0

摘要

目的:在儿童急性淋巴细胞白血病(ALL)中,由于近年来治疗策略的发展,获得了很好的结果。然而,治疗期间的急性并发症仍然是死亡率和发病率的重要原因。在这项研究中,急性并发症的发展,在儿童急性淋巴细胞白血病治疗期间进行了评估。方法:回顾性分析2016年至2021年期间根据(ALL Intercontinental berlin - frankfurt - m nster) 2009方案治疗的47例患者的病历。结果:47例患者中,男性28例(59.6%),女性19例(40.4%)。平均诊断年龄5.9±4.2岁。b细胞前ALL 44例(93.6%),t细胞前ALL 3例(6.4%)。47例患者中,高危9例(19.1%),中危32例(68.1%),标准危6例(12.8%)。出现急性并发症38例(80.8%)。在这些并发症中,感染性并发症最为常见,其次是胃肠道并发症、药物相关反应、血栓形成、神经系统和内分泌/代谢并发症。结论:对于可能出现的并发症,应降低怀疑的门槛,在设备齐全、多学科结合的中心,由同一医疗团队对患者进行治疗。特别是在治疗的早期阶段,应采用住院治疗策略。强调住院治疗策略的重要性,特别是在治疗的早期阶段。
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Acute complications observed during intensive chemotherapy in pediatric patients with acute lymphoblastic leukemia: Single-center experience.

Objective: In childhood acute lymphoblastic leukemia (ALL), very promising results were obtained thanks to the developments in treatment strategies in recent years. However, acute complications during treatment continue to be the important causes of mortality and morbidity. In this study, acute complications that develop during the treatment of ALL in childhood were evaluated.

Methods: Medical records of 47 patients treated according to (ALL Intercontinental Berlin-Frankfurt-Münster) 2009 protocol between 2016 and 2021 were evaluated retrospectively.

Results: Of 47 patients, 28 (59.6%) were male and 19 (40.4%) were female. The mean age at diagnosis was 5.9±4.2 years. Forty-four patients (93.6%) were pre-B cell ALL, 3 patients (6.4%) were pre-T cell ALL. Of 47 patients, 9 (19.1%) were high risk, 32 (68.1%) were intermediate risk, and 6 (12.8%) were standard risk. Acute complications developed in 38 patients (80.8%). Among these complications, infectious complications are the most common and these were followed by gastrointestinal complications, drug-related reactions, thrombotic, neurological, and endocrine/metabolic complications, respectively.

Conclusion: In terms of complications that may develop, the threshold of suspicion should be kept low, and patients should be treated with the same medical team in fully equipped centers with a multidisciplinary approach. Inpatient treatment strategies should be applied especially in the early stages of treatment. The importance of inpatient treatment strategy, especially in the early stages of treatment, is emphasized.

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来源期刊
Northern Clinics of Istanbul
Northern Clinics of Istanbul MEDICINE, GENERAL & INTERNAL-
CiteScore
0.40
自引率
0.00%
发文量
48
审稿时长
10 weeks
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