破骨细胞,骨骼雕刻大师。

Deborah J Veis, Charles A O'Brien
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引用次数: 13

摘要

破骨细胞是一种多核细胞,具有吸收骨基质的独特能力。过度生产或激活破骨细胞导致骨骼病变,影响很大一部分人口。虽然已经开发出有效靶向破骨细胞的治疗方法,但它们有时会产生严重的副作用,对破骨细胞生物学的更全面了解可能会导致更具体的治疗方法。沿着这些思路,大量的工作已经定义了破骨细胞形成、功能和存活所需的基本信号通路。尽管如此,最近的研究对这些细胞在发育和体内平衡期间的起源、它们的寿命以及在体内平衡和疾病期间驱动它们产生和活动的因素的细胞来源等长期持有的观点有了新的认识。在这篇综述中,我们在现有工作的背景下讨论了这些新发现,并强调了正在进行和未来研究的领域。
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Osteoclasts, Master Sculptors of Bone.

Osteoclasts are multinucleated cells with the unique ability to resorb bone matrix. Excessive production or activation of osteoclasts leads to skeletal pathologies that affect a significant portion of the population. Although therapies that effectively target osteoclasts have been developed, they are associated with sometimes severe side effects, and a fuller understanding of osteoclast biology may lead to more specific treatments. Along those lines, a rich body of work has defined essential signaling pathways required for osteoclast formation, function, and survival. Nonetheless, recent studies have cast new light on long-held views regarding the origin of these cells during development and homeostasis, their life span, and the cellular sources of factors that drive their production and activity during homeostasis and disease. In this review, we discuss these new findings in the context of existing work and highlight areas of ongoing and future investigation.

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来源期刊
CiteScore
62.60
自引率
0.00%
发文量
40
期刊介绍: The Annual Review of Pathology: Mechanisms of Disease is a scholarly journal that has been published since 2006. Its primary focus is to provide a comprehensive overview of recent advancements in our knowledge of the causes and development of significant human diseases. The journal places particular emphasis on exploring the current and evolving concepts of disease pathogenesis, as well as the molecular genetic and morphological changes associated with various diseases. Additionally, the journal addresses the clinical significance of these findings. In order to increase accessibility and promote the broad dissemination of research, the current volume of the journal has transitioned from a gated subscription model to an open access format. This change has been made possible through the Annual Reviews' Subscribe to Open program, which allows all articles published in this volume to be freely accessible to readers. As part of this transition, all articles in the journal are published under a Creative Commons Attribution (CC BY) license, which encourages open sharing and use of the research.
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