C Marín-Tello, P Jintaridth, F Sanchez, C González, L Zelada-Castillo, A Vásquez-Arqueros, A Guevara-Vásquez, A Vieira
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引用次数: 0
摘要
肠道微生物群能代谢食物成分，如膳食纤维和各种植物化学物质；微生物群还能合成某些营养素，如 B 族维生素。结肠中的细菌和其他微生物产生的代谢物会对健康和疾病风险产生影响。其中一些代谢物具有表观遗传活性，可通过影响表观遗传活性酶（如组蛋白去乙酰化酶和 DNA 甲基转移酶）的活性和表达，促使染色质的化学修饰和结构发生变化。本文对这类肠道微生物代谢物的表观遗传活性进行了综述。
Epigenetic regulation by metabolites from the gut microbiome.
The gut microbiome can metabolise food components, such as dietary fibres and various phytochemicals; and the microbiome can also synthesise some nutrients, for example B vitamins. The metabolites produced by bacteria and other micro-organisms in the colon can have implications for health and disease risk. Some of these metabolites are epigenetically active, and can contribute to changes in the chemical modification and structure of chromatin by affecting the activity and expression of epigenetically-active enzymes, for example histone deacetylases and DNA methyltransferases. The epigenetic activity of such gut microbiome metabolites is reviewed herein.
期刊介绍：
Beneficial Microbes is a peer-reviewed scientific journal with a specific area of focus: the promotion of the science of microbes beneficial to the health and wellbeing of man and animal. The journal contains original research papers and critical reviews in all areas dealing with beneficial microbes in both the small and large intestine, together with opinions, a calendar of forthcoming beneficial microbes-related events and book reviews. The journal takes a multidisciplinary approach and focuses on a broad spectrum of issues, including safety aspects of pro- & prebiotics, regulatory aspects, mechanisms of action, health benefits for the host, optimal production processes, screening methods, (meta)genomics, proteomics and metabolomics, host and bacterial physiology, application, and role in health and disease in man and animal. Beneficial Microbes is intended to serve the needs of researchers and professionals from the scientific community and industry, as well as those of policy makers and regulators.
The journal will have five major sections:
* Food, nutrition and health
* Animal nutrition
* Processing and application
* Regulatory & safety aspects
* Medical & health applications
In these sections, topics dealt with by Beneficial Microbes include:
* Worldwide safety and regulatory issues
* Human and animal nutrition and health effects
* Latest discoveries in mechanistic studies and screening methods to unravel mode of action
* Host physiology related to allergy, inflammation, obesity, etc.
* Trends in application of (meta)genomics, proteomics and metabolomics
* New developments in how processing optimizes pro- & prebiotics for application
* Bacterial physiology related to health benefits
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