长链非编码rna:糖尿病视网膜病变的关键表观遗传调控因子。

IF 1.8 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Current Genomics Pub Date : 2022-08-11 DOI:10.2174/1389202923666220531105035

Zhaoxia Song, Chang He, Jianping Wen, Jianli Yang, Peng Chen

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引用次数: 1

摘要

糖尿病视网膜病变(DR)是糖尿病的严重并发症;然而，其机制尚不完全清楚。最近有证据表明，长链非编码rna (lncRNAs)在DR中异常表达，并且lncRNAs可能起关键调节作用。LncRNAs可以作为组蛋白修饰复合物的支架和与microRNAs (miRNAs)结合的海绵，在表观遗传水平上调节基因表达。LncRNAs被认为是重要的表观遗传调控因子，可能在DR的诊断和治疗中发挥作用，但LncRNAs在DR中的作用机制尚不清楚。本文就lncrna在DR进展过程中调控靶基因的可能功能和机制进行综述。

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Long Non-coding RNAs: Pivotal Epigenetic Regulators in Diabetic Retinopathy.

Diabetic retinopathy (DR) is a severe complication of diabetes; however, its mechanism is not fully understood. Evidence has recently revealed that long non-coding RNAs (lncRNAs) are abnormally expressed in DR, and lncRNAs may function as pivotal regulators. LncRNAs are able to modulate gene expression at the epigenetic level by acting as scaffolds of histone modification complexes and sponges of binding with microRNAs (miRNAs). LncRNAs are believed to be important epigenetic regulators, which may become beneficial in the diagnosis and therapy of DR. However, the mechanisms of lncRNAs in DR are still unclear. In this review, we summarize the possible functions and mechanisms of lncRNAs in epigenetic regulation to target genes in the progression of DR.

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来源期刊

Current Genomics 生物-生化与分子生物学

CiteScore

5.20

自引率

0.00%

发文量

审稿时长

>0 weeks

期刊介绍： Current Genomics is a peer-reviewed journal that provides essential reading about the latest and most important developments in genome science and related fields of research. Systems biology, systems modeling, machine learning, network inference, bioinformatics, computational biology, epigenetics, single cell genomics, extracellular vesicles, quantitative biology, and synthetic biology for the study of evolution, development, maintenance, aging and that of human health, human diseases, clinical genomics and precision medicine are topics of particular interest. The journal covers plant genomics. The journal will not consider articles dealing with breeding and livestock. Current Genomics publishes three types of articles including: i) Research papers from internationally-recognized experts reporting on new and original data generated at the genome scale level. Position papers dealing with new or challenging methodological approaches, whether experimental or mathematical, are greatly welcome in this section. ii) Authoritative and comprehensive full-length or mini reviews from widely recognized experts, covering the latest developments in genome science and related fields of research such as systems biology, statistics and machine learning, quantitative biology, and precision medicine. Proposals for mini-hot topics (2-3 review papers) and full hot topics (6-8 review papers) guest edited by internationally-recognized experts are welcome in this section. Hot topic proposals should not contain original data and they should contain articles originating from at least 2 different countries. iii) Opinion papers from internationally recognized experts addressing contemporary questions and issues in the field of genome science and systems biology and basic and clinical research practices.