接触性运动与慢性创伤性脑病或神经退行性衰退有关吗?系统回顾和荟萃分析。

IF 1.3 4区 医学 Q4 CLINICAL NEUROLOGY Journal of neurosurgical sciences Pub Date : 2024-02-01 Epub Date: 2023-02-13 DOI:10.23736/S0390-5616.22.05895-7
Meredith A Monsour, Daniel I Wolfson, Jacob Jo, Douglas P Terry, Scott L Zuckerman
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引用次数: 0

摘要

引言:我们试图评估参与接触性和非接触性运动与长期神经系统结果和慢性创伤性脑病(CTE)之间的潜在联系:在 PubMed/Embase/PsycINFO/CINAHL 数据库中查询了 1950-2020 年间有关接触性和非接触性运动、纵向评估 >10 年以及四个领域的长期神经学结果的研究:I) 临床诊断;II) CTE 神经病理学;III) 神经认知;IV) 神经影像学:在 2561 项研究中,37 项符合纳入标准,19 项包含可用于荟萃分析的同质结果。领域 I:在六项研究中,参与接触性体育运动与死前神经退行性疾病诊断或与此类诊断相关的死亡之间无显著关系(RR1.88,P=0.054,95%CI0.99,3.49);但具有边际显著性(PC结论:参与接触性体育运动与死前神经退行性疾病诊断或与此类诊断相关的死亡之间无显著关系(RR1.88,P=0.054,95%CI0.99,3.49)):没有发现神经退行性疾病诊断、CTE 神经病理学或神经认知变化的风险增加与接触性运动的参与有统计学意义,但在两个领域有边际显著性。少数成像比较显示出临床意义不确定的差异。这些结果凸显了使用标准化接触性运动参与和神经退行性疾病标准进行纵向调查的必要性。
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Is contact sport participation associated with chronic traumatic encephalopathy or neurodegenerative decline? A systematic review and meta-analysis.

Introduction: We sought to evaluate a potential association between contact vs. non-contact sport participation and long-term neurologic outcomes and chronic traumatic encephalopathy (CTE).

Evidence acquisition: PubMed/Embase/PsycINFO/CINAHL databases were queried for studies between 1950-2020 with contact and non-contact sports, longitudinal assessment >10 years, and long-term neurologic outcomes in four-domains: I) clinical diagnosis; II) CTE neuropathology; III) neurocognition; and IV) neuroimaging.

Evidence synthesis: Of 2561 studies, 37 met inclusion criteria, and 19 contained homogenous outcomes usable in the meta-analysis. Domain I: Across six studies, no significant relationship was seen between contact sport participation and antemortem diagnosis of neurodegenerative disease or death related to such a diagnosis (RR1.88, P=0.054, 95%CI0.99, 3.49); however, marginal significance (P<0.10) was obtained. Domain II: Across three autopsy studies, no significant relationship was seen between contact sport participation and CTE neuropathology (RR42.39, P=0.086, 95%CI0.59, 3057.46); however, marginal significance (P<0.10) was obtained. Domain III: Across five cognitive studies, no significant relationship was seen between contact sport participation and cognitive function on the Trail Making Test (TMT) scores A/B (A:d=0.17, P=0.275,95% CI-0.13, 0.47; B:d=0.13, P=0.310, 95%CI-0.12, 0.38). Domain IV: In 10 brain imaging-based studies, 32% comparisons showed significant differences between those with a history of contact sport vs. those without.

Conclusions: No statistically significant increased risk of neurodegenerative diagnosis, CTE neuropathology, or neurocognitive changes was found to be associated with contact sport participation, yet marginal significance was obtained in two domains. A minority of imaging comparisons showed differences of uncertain clinical significance. These results highlight the need for longitudinal investigations using standardized contact sport participation and neurodegenerative criteria.

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来源期刊
Journal of neurosurgical sciences
Journal of neurosurgical sciences CLINICAL NEUROLOGY-SURGERY
CiteScore
3.00
自引率
5.30%
发文量
202
审稿时长
>12 weeks
期刊介绍: The Journal of Neurosurgical Sciences publishes scientific papers on neurosurgery and related subjects (electroencephalography, neurophysiology, neurochemistry, neuropathology, stereotaxy, neuroanatomy, neuroradiology, etc.). Manuscripts may be submitted in the form of ditorials, original articles, review articles, special articles, letters to the Editor and guidelines. The journal aims to provide its readers with papers of the highest quality and impact through a process of careful peer review and editorial work.
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